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Recombinant Mouse TNF receptor-associated factor 5 (Traf5)

Recombinant Mouse TNF receptor-associated factor 5 (Traf5)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Traf5

Uniprot NO.

P70191

Alternative Names

Traf5; TNF receptor-associated factor 5

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-558

Target Protein Sequence

MAHSEEQAAV PCAFIRQNSG NSISLDFEPD TEYQFVEQLE ERYKCAFCHS VLHNPHQTGC GHRFCQQCIR SLRELNSVPI CPVDKEVIKP QEVFKDNCCK REVLNLHVYC KNAPGCNARI ILGRFQDHLQ HCSFQAVPCP NESCREAMLR KDVKEHLSAY CRFREEKCLY CKRDIVVTNL QDHEENSCPA YPVSCPNRCV QTIPRARVNE HLTVCPEAEQ DCPFKHYGCT VKGKRGNLLE HERAALQDHM LLVLEKNYQL EQRISDLYQS LEQKESKIQQ LAETVKKFEK ELKQFTQMFG RNGTFLSNVQ ALTSHTDKSA WLEAQVRQLL QIVNQQPSRL DLRSLVDAVD SVKQRITQLE ASDQRLVLLE GETSKHDAHI NIHKAQLNKN EERFKQLEGA CYSGKLIWKV TDYRVKKREA VEGHTVSVFS QPFYTSRCGY RLCARAYLNG DGSGKGTHLS LYFVVMRGEF DSLLQWPFRQ RVTLMLLDQS GKKNHIVETF KADPNSSSFK RPDGEMNIAS GCPRFVSHST LENSKNTYIK DDTLFLKVAV DLTDLEDL
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR.

Gene References into Functions

TRAF5 is crucially involved in OSM-mediated lung inflammation probably by inducing lung stromal/fibroblast cell activation. PMID:29596835
our data indicate that Berberine exerts protective effects against chronic renal failurepartly through the TRAF5-mediated activation of the NF-kappaB signaling pathway in mouse podocytes PMID:29115406
The results indicated that TRAF5 deficiency significantly aggravated DSS-induced colitis, most likely by regulating Th cell-mediated inflammation. PMID:27110068
In conclusion, our results suggest that as an intrinsic cardioprotective factor, TRAF5 plays a crucial role in the development of cardiac hypertrophy through the negative regulation of the MEK-ERK1/2 pathway PMID:24038435
knock-out mice develop exaggerated experimental autoimmune encephalomyelitis due to enhanced Th17 cell differentiation PMID:24681564
TRAF5 negatively regulates TLR signaling in B lymphocytes. PMID:24259503
These results provide the first demonstration that TRAF5 is a critical mediator of brain ischemia/reperfusion in an experimental stroke model. PMID:23413803
Treatment with IL-17 prolongs the half-life of chemokine CXCL1 mRNA via the adaptor TRAF5 and the splicing-regulatory factor SF2 (ASF). PMID:21822258
TNF receptor-associated factor 5 (TRAF5) deficiency accelerates atherogenesis in mice by increasing inflammatory cell recruitment and foam cell formation. PMID:20651286
Study is the first report showing a major requirement for TRAF5 in signaling by a specific receptor both in vitro and in vivo, as well as playing an important role in biological function in B lymphocytes. PMID:19805155
role in both RANKL- and TNFalpha-induced osteoclastogenesis PMID:12619928
TRAF5 has a role in TNF-alpha induced IKK phosphorylation of NF-kappaB p65 PMID:12842894
TRAF5 plays a limiting role during the differentiation of type 2 helper (Th2) cells by limiting certain responses driven by costimulatory molecules such as OX40/CD134. PMID:15034043
Traf5 is a critical intermediate of costimulatory signaling pathways triggered by glucocorticoid-induced TNFR in T-lymphocytes. PMID:16452475
TRAF5 as an important positive signaling element that enhances T cell expansion and pathogen containment by providing a survival advantage to responding Ag-specific CD8(+) T cells during infection. PMID:19017969