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Recombinant Mouse TNF receptor-associated factor 4 (Traf4)

Recombinant Mouse TNF receptor-associated factor 4 (Traf4)

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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Traf4

Uniprot NO.

Q61382

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-470

Target Protein Sequence

MPGFDYKFLE KPKRRLLCPL CGKPMREPVQ VSTCGHRFCD TCLQEFLSEG VFKCPEDQLP LDYAKIYPDP ELEVQVLGLA IRCIHSEEGC RWSGPLRHLQ GHLNTCSFNV VPCPNRCPAK LSRRDLPAHL QHDCPKRRLK CEFCGCDFSG EAYESHEGVC PQESVYCENK CGARMMRRLL AQHATSECPK RTQPCAYCTK EFVYDTIQSH QYQCPRLPVP CPNQCGVGTV AREDLPTHLK DSCSTAFVLC PFKESGCKHR CPKLAMGRHV EESVKPHLAM MCALVSRQRQ ELQELRRELE ELSIGSDGVL IWKIGSYGRR LQEAKAKPNL ECFSPAFYTH KYGYKLQVSA FLNGNGSGEG THLSIYIRVL PGAFDNLLEW PFARRVTFSL LDQSDPGLAK PQHVTETFHP DPNWKNFQKP GTWRGSLDES SLGFGYPKFI SHQDIRKRNY VRDDAVFIRA SVELPRKILS

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Description

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Target Background

Function

Adapter protein with E3 ligase activity that is involved in many diverse biological processes including cell proliferation, migration, differentiation, DNA repair, platelet activation or apoptosis. Promotes EGFR-mediated signaling by facilitating the dimerization of EGFR and downstream AKT activation thereby promoting cell proliferation. Ubiquitinates SMURF2 through 'Lys-48'-linked ubiquitin chain leading to SMURF2 degradation through the proteasome and subsequently osteogenic differentiation. Promotes 'Lys-63'-mediated ubiquitination of CHK1 which in turn activates cell cycle arrest and activation of DNA repair. In addition, promotes an atypical 'Lys-29'-linked ubiquitination at the C-terminal end of IRS1 which is crucial for insulin-like growth factor (IGF) signal transduction. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract. Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions. Inhibits adipogenic differentiation by activating pyruvate kinase PKM activity and subsequently the beta-catenin signaling pathway.

Gene References into Functions

TRAF4 knockdown significantly inhibited proliferation, invasion and metastasis in the xenograft nude mouse model, possibly involving in the interaction with RSK4. PMID:29684350
A novel IL-17 signaling pathway controlling keratinocyte proliferation and tumorigenesis via the TRAF4-ERK5 axis. PMID:26347473
Data indicate that TNF receptor associated factor 4 (TRAF4) recruited the E3-ligase SMURF2, to degrade the IL-25R-inhibitory molecule DAZ associated protein 2 (DAZAP2). PMID:25681341
Like IKKalpha, TRAF4 is atypical within its family because it is the only TRAF family member to negatively regulate innate immune signaling. IKKalpha's phosphorylation of serine-426 on TRAF4 was required for this negative regulation. PMID:22547678
These results provide conclusive evidence for the pivotal contribution of TRAF4 to myelination. PMID:22363515
enhances TNF-alpha translation PMID:21494017
A novel motif in the Crohn's disease susceptibility protein, NOD2, allows TRAF4 to down-regulate innate immune responses. PMID:21097508
Impaired neural tube closure, axial skeleton malformations, and tracheal ring disruption in TRAF4-deficient mice. PMID:11943846
TRAF4 may play a role in p53-mediated proapoptotic signaling in the response to cellular stress PMID:12788948
MEKK4 is the MAPK kinase kinase for TRAF4 regulation of the JNK pathway PMID:16157600

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Subcellular Location

Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Cell junction, tight junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton.

Protein Families

TNF receptor-associated factor family, B subfamily

Tissue Specificity

Predominantly expressed in brain. Preferentially expressed by postmitotic undifferentiated neurons in developing central (CNS) and peripheral (PNS) nervous system, and in nervous tissues of sensory organs. In the embryo, protein expression was shown in br

Database Links

UNIGENE: Mm.390418

KEGG: mmu:22032

STRING: 10090.ENSMUSP00000017530

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