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Recombinant Mouse TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Tab3)

Recombinant Mouse TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Tab3)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Tab3

Purity

>85% (SDS-PAGE)

Target Names

Tab3

Uniprot NO.

Q571K4

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

2-716

Target Protein Sequence

AQNSPQLDI QVLHDLRQRF PEIPEGVVSQ CMLQNNNNLE ACCRALSQES SKYLYMEYHS PEDNRMNRNR LLHINLGIHS PSSYHPGDGA HLNGGRTLVH SSSDGHIDPQ HTAGKQLICL VQEPHSAPAV VAATPNYNPF FMNEQNRSAA TPPSQPPQQP SSMQTGMNPS AMQGPSPPPP PPSYMHIPRY STNPITVTVS QNLPSGQTVP RALQILPQIP SNLYGSPGSI FIRQTSQSSS GRQTPQNAPW QSSPQGPVPH YSQRPLPVYP HQQNYQPSQY SPKQQQIPQS VYHSPPPSQC PSPFSSPQHQ VQPPQLGHPS SHVFMPPSPS TTPPHLYQQG PPSYQKPGSH SVAYLPYTAS SLPKGSMKKI EITVEPSQRP GTAITRSPSP ISNQPSPRNQ HSLYTATTPP SSSPSRGISS QPKPPFSVNP VYITYTQPTG PSCAPSPSPR VIPNPTTVFK ITVGRATTEN LLNLVDQEER SAAPEPIQPI SVIPGSGGEK GNHKYQRSSS SGSDDYAYTQ ALLLHQRARM ERLAKQLKLE KEELERLKAE VNSMEHDLMQ RRLRRVSCTT AIPTPEEMTR LRSTNRQLQI NVDCTLKEVD LLQSRGNFDP KAINNFYDHI EPGPVVPPKP SKKDSSDSCA IERKARRISV TSKAPVDIHD AQAAAADEHL SICKQSARTQ PRDEDYEGAP WNCDSCTFLN HPALNRCEQC EMPRYT
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains. The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1.

Gene References into Functions

Findings indicate that the absence of TAB3 plays a harmful role in ischemic heart disease PMID:28462515
TAB2 and TAB3 are essential for B cell activation leading to antigen-specific antibody responses, as well as B-1 and marginal zone B cell development. PMID:23509369
MiR-23b suppresses IL-17-, tumor necrosis factor alpha (TNF-alpha)- or IL-1beta-induced NF-kappaB activation and inflammatory cytokine expression by targeting TAB2, TAB3 and IKK-alpha. PMID:22660635

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Database Links

UNIGENE: Mm.119646

KEGG: mmu:66724

STRING: 10090.ENSMUSP00000039668

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