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Recombinant Mouse Synaptonemal complex protein 1 (Sycp1), partial

Recombinant Mouse Synaptonemal complex protein 1 (Sycp1), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Sycp1

Purity

>85% (SDS-PAGE)

Target Names

Sycp1

Uniprot NO.

Q62209

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-993

Target Protein Sequence

MEKQKPFTLF VPPRLSSSQV SAVKPQTAGG DSNYFKTANK CTEGDFGVPF TMSSRENIDK DPAFQKLSIL PMLEQVANSG SCHYQEGVND SDFENSEPMS RLYSKLYKEA EKIKKWKVSI ESELKQKENK LQENRKIIEA QRKAIQELQF ENEKVSLKLE EEIQENKDLI KENNATIHWC NLLKETCARS AEKTNKYEYE REETRQVYVD LNSNIEKMIL AFEELRVQAE NARLEMHFKL KEDHEKIQHL EEEYQKEVNN KENQVSELLI QSAEKENKMK DLTFLLEESR DKANQLEEKT KLQDENLKEL SEKKDHLTSE LEDIKMSMQR SMSTQKALEE DLQIATKTIS QLTEVKEAQM EELNKAKTTH SFVVTELKAT TCTLEELLRT EQQRLEKNED QLKLITVELQ KKSNELEEMT KFKNNKEVEL EELKNILAED QKLLDEKKQV EKLAEELQEK EQELTFLLET REKEVHDLQE QVTVTKTSEQ HYLKQVEEMK TELEKEKLKN TELTASCDML LLENKKFVQE ASDMALELKK HQEDIINCKK QEERLLKQIE NLEEKEMHLR DELESVRKEF IQQGDEVKCK LDKSEENARS IECEVLKKEK QMKILESKCN NLKKQVENKS KNIEELHQEN KTLKKKSSAE IKQLNAYEIK VSKLELELES TKQRFEEMTN NYQKEIENKK ISEGKLLGEV EKAKATVDEA VKLQKEIDLR CQHKIAEMVA LMEKHKHQYD KIVEERDSEL GLYKNREQEQ SSAKIALETE LSNIRNELVS LKKQLEIEKE EKEKLKMAKE NTAILKDKKD KKIQASLLES PEATSWKFDS KTTPSQNISR LSSSMDSGKS KDNRDNLRAS AKSILPTTVT KEYTVKTPTK KSIYQRENKY IPTGGSNKKR KTAFEFDVNS DSSETADLLS LVSEEDVSNR LYDNNPPDSH LLVKTPKQTP LSLSTPASFM KFGSLKKMRE DRWTTIAKID RKRRLKEAEK LFS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Major component of the transverse filaments of synaptonemal complexes, formed between homologous chromosomes during meiotic prophase. Required for normal assembly of the central element of the synaptonemal complexes. Required for normal centromere pairing during meiosis. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility.

Gene References into Functions

Sororin localizes to the cores of meiotic chromosomes in a manner that is dependent on synapsis and the synaptonemal complex protein SYCP1. PMID:28050734
PLK1, but not PLK2-4, phosphorylates central element proteins SYCP1 and TEX12. PMID:22854038
SYCP1 and SYCP3 act at the centromeres to promote the establishment and/or maintenance of centromere pairing and, by doing so, improve the segregation fidelity of mammalian meiotic chromosomes. PMID:22761579
SYCP1 has a coordinating role, and ensures formation of crossovers PMID:15937223
The localisation of Syce1 and Cesc1 (Syce2) to the central element depends on recruitment by Sycp1. PMID:15944401