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Recombinant Mouse Sodium-dependent phosphate transport protein 2B (Slc34a2), partial

Recombinant Mouse Sodium-dependent phosphate transport protein 2B (Slc34a2), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Slc34a2

Purity

>85% (SDS-PAGE)

Target Names

Slc34a2

Uniprot NO.

Q9DBP0

Species

Mus musculus (Mouse)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs' alveoli.

Gene References into Functions

Npt2b deficiency did not affect Pi absorption within the range of Pi concentrations that normally occurs after meals. PMID:29128884
This study validated the role of Npt2b in the pathogenesis of Pulmonary alveolar microlithiasis (PAM). PMID:26560359
Overall, our preclinical results suggest that the ADC targeting NaPi2b provides an effective new therapy for the treatment of NSCLC and ovarian cancer and is currently undergoing clinical developments. PMID:26156394
NaPi-IIb is the only luminal Na(+) -dependent Pi transporter in the murine ileum and its absence is fully compensated for in adult females by a mechanism involving the bone-kidney axis. PMID:25827490
Knockdown of the sodium-dependent phosphate co-transporter 2b (NPT2b) suppresses lung tumorigenesis. PMID:24194864
B-RAF increases the cell surface protein abundance and activity of the type II Na+-coupled phosphate transporters NaPi-IIa and NaPi-IIb. PMID:24258620
that NHERF1 associates with NaPi-2b in enterocytes and regulates NaPi-2b adaptation. PMID:22904329
Compared with wild-type uremic mice, Npt2b-deficient uremic mice had significantly lower levels of serum phosphate and attenuation of FGF23. PMID:22859851
Npt2b is an important target for the prevention of hyperphosphatemia PMID:21816756
NaPi-IIb was the predominantly expressed epithelial isoform of the sodium-inorganic phosphate cotransporter and was markedly overexpressed in the proximal region in the infertile knockout compared to the fertile heterozygous c-ros transgenic mouse PMID:12773415
SGK1 stimulates the NaPi IIb, at least in part, by phosphorylating and thereby inhibiting Nedd4-2 binding to its target. PMID:15044175
along the entire mouse small intestine, low-phosphate diet affects transcription and/or the stability of NaPi-IIb mRNA PMID:15701623
NaPi-IIb expression was found to be mainly confined to the ileum in the small intestine PMID:15701624
In the steady state, NaPi-IIb showed a curvilinear I-V relationship, with rate-limiting behavior only for depolarizing potentials. PMID:17342377
Expression patterns of NaPi-IIb suggest that NaPi-IIb plays an important role in Pi absorption from maternal circulation. PMID:19233126