Recombinant Mouse Sialin (Slc17a5), partial

Code
MSDS	MSDS
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Slc17a5

Uniprot NO.

Q8BN82

Species

Mus musculus (Mouse)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Description

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Target Background

Function

Transports glucuronic acid and free sialic acid out of the lysosome after it is cleaved from sialoglycoconjugates undergoing degradation, this is required for normal CNS myelination. Mediates aspartate and glutamate membrane potential-dependent uptake into synaptic vesicles and synaptic-like microvesicles. Also functions as an electrogenic 2NO(3)(-)/H(+) cotransporter in the plasma membrane of salivary gland acinar cells, mediating the physiological nitrate efflux, 25% of the circulating nitrate ions is typically removed and secreted in saliva.

Gene References into Functions

This study demonstrated that Progressive leukoencephalopathy impairs neurobehavioral development in sialin-deficient mice. PMID:28189729
Autophagy regulates the stability of sialin, a lysosomal sialic acid transporter. PMID:25494612
The uptake of N-acetylaspartylglutamate into synaptic vesicles depends on sialic acid transporter sialin, SLC17A5. PMID:23889254
l-aspartate is exocytotically released from nerve terminals after vesicular accumulation by a transporter other than sialin. PMID:23221336
These findings suggest that a defect in maturation of cells in the oligodendrocyte lineage leads to increased apoptosis and underlies the myelination defect associated with sialin loss. PMID:20007460
sialin possesses dual physiological functions and acts as a vesicular aspartate/glutamate transporter PMID:18695252

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Subcellular Location

Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.

Protein Families

Major facilitator superfamily, Sodium/anion cotransporter family

Database Links

UNIGENE: Mm.46932

KEGG: mmu:235504

STRING: 10090.ENSMUSP00000056182

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