Home
Product
Protein
Recombinant Proteins
Recombinant Mouse Serine/threonine-protein phosphatase 6 catalytic subunit (Ppp6c)

Recombinant Mouse Serine/threonine-protein phosphatase 6 catalytic subunit (Ppp6c)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
Have Questions?	Leave a Message or Start an on-line Chat

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Abbreviation

Ppp6c

Purity

>85% (SDS-PAGE)

Target Names

Ppp6c

Uniprot NO.

Q9CQR6

Alternative Names

Ppp6c; Serine/threonine-protein phosphatase 6 catalytic subunit; PP6C; EC 3.1.3.16

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-305

Target Protein Sequence

MAPLDLDKYV EIARQCKYLP ENDLKRLCDY VCDLLLEESN VQPVSTPVTV CGDIHGQFYD LCELFRTGGQ VPDTNYIFMG DFVDRGYYSL ETFTYLLALK AKWPDRITLL RGNHESRQIT QVYGFYDECQ TKYGNANAWR YCTKVFDMLT VAALIDEQIL CVHGGLSPDI KTLDQIRTIE RNQEIPHKGA FCDLVWSDPE DVDTWAISPR GAGWLFGAKV TNEFVHINNL KLICRAHQLV HEGYKFMFDE KLVTVWSAPN YCYRCGNIAS IMVFKDVNTR EPKLFRAVPD SERVIPPRTT TPYFL
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

Submit a Review here

Target Background

Function(From Uniprot)

Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. During mitosis, regulates spindle positioning. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7. Participates also in the innate immune defense against viruses by desphosphorylating RIG-I/DDX58, an essential step that triggers RIG-I/DDX58-mediated signaling activation.

Gene References into Functions

Ppp6c deficiency enhances K-ras(G12D) -dependent tumor promotion PMID:29758119
the Ppp6c phosphatase domain is indispensable for mouse embryogenesis after implantation. PMID:26868000
findings uncover a hitherto unknown role for PP6 as an indispensable regulator of oocyte meiosis and female fertility. PMID:26349807
Data identify NF-kappaB-induced miR-31 and its target, ppp6c, as critical factors for the hyperproliferation of epidermis in psoriasis. PMID:26138368
Ppp6c deficiency predisposes mice to skin carcinogenesis initiated by DMBA. PMID:25486434
Ppp6c deficiency underlies molecular events that drive outgrowth of initiated keratinocytes harboring UVB-induced mutated p53 PMID:26054846
Our studies demonstrate that PP6 acts as a critical negative regulator of naive T cell homeostasis PMID:25609840
PP6 regulates the sensitivity of GBM cells to radiation, and suggest small molecules disrupting or inhibiting PP6 association with DNA-PK is a potential radiosensitizer for GBM. PMID:22158480
alpha4 expression differentially increased or decreased phosphorylation of endogenous phosphoproteins, consistent with opposing effects on PP2A and PP6 [PP6] PMID:16895907

Hide All

Subcellular Location

Mitochondrion. Cytoplasm.

Protein Families

PPP phosphatase family, PP-6 (PP-V) subfamily

Tissue Specificity

Ubiquitously expressed in all tissues tested with strongest expression in lung, spleen, liver, kidney and brain. Weaker expression observed in bladder, pancreas, heart and skeletal muscle.

Database Links

UNIGENE: Mm.389242

KEGG: mmu:67857

STRING: 10090.ENSMUSP00000028087

Promotions