Recombinant Mouse Serine/threonine-protein kinase ULK1 (Ulk1), partial

1. Ulk1-Knockout mice show reduced inflammation and apoptosis in hippocampus after traumatic brain injury. PMID:29680658
2. The authors described a long-distance signaling mechanism of Porcine hemagglutinating encephalomyelitis virus-driven deficits in neurons and suggested that such Ulk1 repression may result in limited NGF/TrkA retrograde signaling within activated Rab5 endosomes, explaining the progressive failure of neurite outgrowth and survival. PMID:29875237
3. Authors conclude that miR-93 is involved in hypoxia-induced autophagy by regulating ULK1. Results provide a new angle to understand the complicated regulation of the key autophagy kinase ULK1 during different stress conditions. PMID:29109831
4. Ampk is required for exercise-induced phosphorylation of Ulk1. PMID:28916822
5. We created Smcr8 knockout mice and found that Smcr8 mutant cells exhibit impaired autophagy induction, which is similarly observed in C9orf72 knockdown cells. Mechanistically, SMCR8/C9ORF72 interacts with the key autophagy initiation ULK1 complex and regulates expression and activity of ULK1 PMID:27617292
6. ATG7, but not ATG13 or ULK1 has a role in functional autophagy in glioblastoma development PMID:27304681
7. ULK1 is a novel substrate of Caspase-3 and upregulation of ULK1 drives autophagy initiation in leukemia cells. PMID:28381396
8. Findings indicate that the PPM1D-Ulk1 axis plays a pivotal role in genotoxic stress-induced autophagy. PMID:27670885
9. Regulation of endoplasmic reticulum-to-Golgi trafficking by ULK1/2 is essential for cellular homeostasis. PMID:27203176
10. Ulk1-mediated autophagy plays an essential role in mitochondrial remodeling and functional regeneration of skeletal muscle. PMID:28356270
11. ULK1/2 function as a bifurcate-signaling node that sustains glucose metabolic fluxes besides initiation of autophagy in response to nutritional deprivation. PMID:27153534
12. These results define a key molecular event for the starvation-induced activation of the ATG14-containing PtdIns3K complex by ULK1. PMID:27046250
13. By enhancing PARP1 activity, ULK1 contributes to ATP depletion and death of H2O2-treated cells. PMID:26138443
14. MUL1 ubiquitinates ULK1 and regulates selenite-induced mitophagy PMID:26018823
15. autophagy can be executed by mechanisms that are dependent or independent of the ULK1/2-ATG13 interaction. PMID:26213203
16. MiR-17-5p may be able to arrest the maturation of mycobacterial phagosomes in part by targeting ULK1, subsequently reduces the ability of host cells to kill intracellular Camette-Guerin bacillus. PMID:26384021
17. Study identifies a key role of Cul3-KLHL20 in autophagy termination by controlling autophagy-dependent turnover of ULK1 and VPS34 complex subunits and reveals the pathophysiological functions of this autophagy termination mechanism. PMID:26687681
18. Concurrent mTORC1 inactivation and PP2A-B55alpha stimulation fuel ULK1-dependent autophagy. PMID:26310906
19. AnxA2 regulates autophagy, thereby contributing to host immunity against bacteria through the Akt1-mTOR-ULK1/2 signaling pathway PMID:26371245
20. Nitric oxide also stabilized an autophagy-related protein unc-51 like kinase (ULK1), but did not restore SIRT1 protein levels in ULK1-siRNA-treated cells or in mouse embryonic fibroblasts (MEF) from Ulk1-/- mice. PMID:25541949
21. Ulk1-dependent Atg5-independent macroautophagy is the dominant process of mitochondrial clearance from fetal definitive reticulocytes. PMID:24895007
22. ULK1 knockdown increased neuronal cell viability, and enhanced S6k1 phosphorylation in a dopaminergic neuron model of Parkinson's disease PMID:25680463
23. this study identifies ULK1 as a new p62 Ser403 kinase and establishes Sestrin2 as a promoter of ULK1-mediated p62 phosphorylation. PMID:25040165
24. ULK1, albeit its important autophagic role, regulates lipid metabolism and glucose uptake in adipocytes distinctly from other autophagy proteins. PMID:24135897
25. Analysis of the autophagy signaling pathway showed the existence of a negative feedback loop between the ULK1 and 2 and MTORC1 and 2, in lung tissue. PMID:24275123
26. Data suggest that Ulk1 plays critical role in development of alcoholic cardiomyopathy, that is, autophagy induction, cardiac contractile dysfunction, and intracellular Ca2+ anomalies. PMID:23448468
27. ULK1 and ULK2 have redundant roles in nutrient-dependent activation of autophagy PMID:23291478
28. ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase. PMID:23685627
29. Both AMPK and ULK1 regulate localization of a critical component of the phagophore, ATG9 PMID:22932492
30. In the initial steps of Parkin-mediated mitophagy, the structures containing the ULK1 complex and Atg9A are independently recruited to depolarized mitochondria. PMID:22275429
31. amino acid starvation regulates autophagy in part through an increase in cellular Ca(2+) that activates a CaMKK-beta-AMPK pathway and inhibits mTORC1, which results in ULK1 stimulation PMID:23027865
32. Unexpected and essential role of autophagy during monocyte differentiation and acquisition of macrophage functions. PMID:22452982
33. Phosphorylation of AMPK by Ulk1 represents a negative feedback circuit. PMID:21460634
34. ULK1 and ULK2 are functionally redundant protein kinases required to mediate autophagy under nutrient-deprived conditions in fibroblasts. PMID:21460635
35. the autophagy response to the enhanced amino acid catabolism induced by deprivation of glucose or direct exposure to ammonia does not require ULK1 and/or ULK2 PMID:21690395
36. Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK. PMID:21383122
37. Data show that under nutrient sufficiency, high mTOR activity prevents Ulk1 activation by phosphorylating Ulk1 Ser 757 and disrupting the interaction between Ulk1 and AMPK. PMID:21258367
38. findings uncover a conserved mechanism coupling nutrient status with autophagy and cell survival; loss of AMPK or ULK1 result in defective mitophagy;phosphorylation of ULK1 by AMPK required for mitochondrial homeostasis and cell survival during starvation PMID:21205641
39. Results identified multiple sites of phosphorylation on Ulk1, including several within domains known to regulate macroautophagy, and sites in the C-terminal domain that depend upon or require Ulk1 autophosphorylation. PMID:19807128
40. Complex of Unc51.1/SynGAP1/Syntenin governs axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons PMID:15014045
41. ULK1 is localized to vesicular structures in growth cones of spinal ganglia afferent neurons. RNAi-mediated knockdown of ULK1 resulted in impaired endocytosis of nerve growth factor, excessive axon arborization, and severely stunted axon elongation. PMID:17389358
42. Ulk1, is a component of the selective autophagy machinery that leads to the elimination of organelles in erythroid cells rather that an essential mechanistic component of autophagy PMID:18539900
43. The functions of ULK1 and ULK2 are controlled by autophosphorylation and conformational changes involving exposure of the C-terminal domain and interaction with the putative human homologue of Atg13. PMID:18936157
44. The role of the ULK-FIP200 complex in autophagy and the possibility that FIP200 functions as a mammalian counterpart of Atg17, is reported. PMID:18981720
45. mTORC1 suppresses autophagy through direct regulation of the approximately 3-MDa ULK1-Atg13-FIP200 complex. PMID:19211835
46. ATG13 and ULK1 are phosphorylated by the mTOR pathway in a nutrient starvation-regulated manner, indicating that the ULK1.ATG13.FIP200 complex acts as a node for integrating incoming autophagy signals into autophagosome biogenesis. PMID:19258318

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UNIGENE: Mm.271898

KEGG: mmu:22241

STRING: 10090.ENSMUSP00000031490