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Recombinant Mouse STE20-related kinase adapter protein alpha (Strada)

Recombinant Mouse STE20-related kinase adapter protein alpha (Strada)

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MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Strada

Purity

>85% (SDS-PAGE)

Target Names

Strada

Uniprot NO.

Q3UUJ4

Alternative Names

Strada; Lyk5; Strad; STE20-related kinase adapter protein alpha; STRAD alpha; STE20-related adapter protein

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-431

Target Protein Sequence

MSFLVSKPER IRRWVSEKFI VEGLRDLELF GEQPPGDTRR KANEASSESI ASFSKPEMMS SFLPEGGCYE LLTIIGKGFE DLMTVNLARY KPTGEYVTVR RINLEACSNE MVTFLQGELH VSKLFSHPNI VPYRATFIAD NELWVVTSFM AYGSAKDLIG THFMDGMNEL AIAYILQGVL KALDYIHHMG YVHRSVKASH ILISTDGKVY LSGLRSNLSM ISHGQRQRAV HDFPKYSIKV LPWLSPEVLQ QNLQGYDAKS DIYSVGITAC ELANGHVPFK DMPATQMLLE KLNGTVPCLL DTSTIPAEEL TMSPSRSIAN PGLNDSLAAG SLRPSNGDSP SHPYHRTFSP HFHNFVEQCL QRNPDARPNA STLLNHSFFK QIKRRASEAL PELLRPVTPI TNFEGSQSQD HSGIFGLVTN LEDLEVDDWE F
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.

Gene References into Functions

Quantitative PCR revealed significantly reduced LKB1, MO25alpha, and STRADbeta mRNA in LKB1(-/-) muscle. These findings demonstrate that the LKB1-MO25-STRAD complex is the principal AMPKK in skeletal muscle. PMID:21903876
aberrant nuclear accumulation of LKB1 caused by STRADalpha deficiency contributes to hyperactivation of mTORC1 signaling and disruption of neuronal lamination during corticogenesis PMID:20424326

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Subcellular Location

Nucleus. Cytoplasm.

Protein Families

Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily

Database Links

UNIGENE: Mm.403722

KEGG: mmu:72149

STRING: 10090.ENSMUSP00000007444

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