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Recombinant Mouse Run domain Beclin-1 interacting and cystein-rich containing protein (Kiaa0226), partial

Recombinant Mouse Run domain Beclin-1 interacting and cystein-rich containing protein (Kiaa0226), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Kiaa0226

Purity

>85% (SDS-PAGE)

Target Names

Rubcn

Uniprot NO.

Q80U62

Alternative Names

Rubcn; Kiaa0226; Run domain Beclin-1-interacting and cysteine-rich domain-containing protein; Rubicon

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-956

Target Protein Sequence

MRPEGAGMDL GGGDGERLLE KSRREHWQLL GNLKTTVEGL VSANCPNVWS KYGGLERLCR DMQNILYHGL IHDQVCCRQA DYWQFVKDIR WLSPHSALHV EKFISLHESD QSDTDSVSER AVAELWLQHS LQCHCLSAQL RPLLGDRQYI RKFYTETAFL LSDAHVTAML QCLEAVEQNN PRLLAQIDAS MFARKQESPL LVTKSQSLTA LPGSTYTPPA SYAQHSYFGS SSSLQSMPQS SHSSERRSTS FSLSGPSWQP QEDRECLSPA ETQTTPAPLP SDSTLAQDSP LTAQEMSDST LTSPLEASWV SSQNDSPSDV SEGPEYLAIG NPAPHGRTAS CESHSSNGES SSSHLFSSSS SQKLESAASS LGDQEEGRQS QAGSVLRRSS FSEGQTAPVA SGTKKSHIRS HSDTNIASRG AAGGPRNITI IVEDPIAEGG QYLCSGEGMF RRPSEGQSLI SYLSEQDFGS CADLEKENAH FSISESLIAA IELMKCNMMS QCLEEEEVEE EDSDREIQEL KQKIRLRRQQ IRTKNLLPAY RETENGSFRV TSSSSQFSSR DSTQLSESGS AEDADDLEIQ DADIRRSAVS NGKSSFSQNL SHCFLHSTSA EAVAMGLLKQ FEGMQLPAAS ELEWLVPEHD APQKLLPIPD SLPISPDDGQ HADIYKLRIR VRGNLEWAPP RPQIIFNVHP APTRKIAVAK QNYRCAGCGI RTDPDYIKRL RYCEYLGKYF CQCCHENAQM VVPSRILRKW DFSKYYVSNF SKDLLLKIWN DPLFNVQDIN SALYRKVKLL NQVRLLRVQL YHMKNMFKTC RLAKELLDSF DVVPGHLTED LHLYSLSDLT ATKKGELGPR LAELTRAGAA HVERCMLCQA KGFICEFCQN EEDVIFPFEL HKCRTCEECK ACYHKTCFKS GRCPRCERLQ ARRELLAKQS LESYLSDYEE EPTEALALEA TVLETT
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation.; Involved in regulation of pathogen-specific host defense of activated macrophages. Following bacterial infection promotes NADH oxidase activity by association with CYBA thereby affecting TLR2 signaling and probably other TLR-NOX pathways. Stabilizes the CYBA:CYBB NADPH oxidase heterodimer, increases its association with TLR2 and its phagosome trafficking to induce antimicrobial burst of ROS and production of inflammatory cytokines. Following fungal or viral infection (implicating CLEC7A (dectin-1)-mediated myeloid cell activation or DDX58/RIG-I-dependent sensing of RNA viruses) negatively regulates pro-inflammatory cytokine production by association with CARD9 and sequestering it from signaling complexes.

Gene References into Functions

Rubicon specifically interacts with the interferon regulatory factor (IRF) association domain (IAD) of IRF3, and this interaction leads to inhibition of the dimerization of IRF3, which negatively regulates interferon-mediated antiviral response. PMID:28468885
Rubicon deficiency enhances autophagic flux in the heart and protects mice from lethality and reduction in stroke volume induced by LPS. PMID:25502307
Data indicate that Rubicon (Kiaa0226) and NOX2 (gp91phox) are involved in microtubule-associated protein LC3-associated phagocytosis. PMID:26098576
Beclin 1 and its binding proteins orchestrate the precise function of the class III PI(3)K in regulating autophagy at multiple steps. PMID:19270693
Two Beclin 1 associated proteins, Atg14L and Rubicon, were identified. PMID:19270696

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Subcellular Location

Late endosome. Lysosome. Early endosome. Note=Predominantly located in late endosomes/lysosomes, only partially detected in early endosome and not at all in the Golgi apparatus.

Database Links

UNIGENE: Mm.327319

KEGG: mmu:100502698

STRING: 10090.ENSMUSP00000087114

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