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Recombinant Mouse Retinoblastoma-like protein 1 (Rbl1), partial

Recombinant Mouse Retinoblastoma-like protein 1 (Rbl1), partial

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MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Rbl1

Purity

>85% (SDS-PAGE)

Target Names

Rbl1

Uniprot NO.

Q64701

Alternative Names

Rbl1; Retinoblastoma-like protein 1; 107 kDa retinoblastoma-associated protein; p107; pRb1

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-1063

Target Protein Sequence

MFEDEPHAEG AAAVAAAREA LQALCQELNL DEGSAAEALD DFTAIRGNYS LEGEVIHWLA CSLYVACRKS IIPTVGKGVM EGNCVSLTRI LRSAKLSLIQ FFSKMKKWMD MSNLPQEFRE RIERLERNFE VSTVIFKKFE PIFLDIFQNP YEEPPKLPRS RKQRRIPCSV KDLFNFCWTL FVYTKGNFRM IGDDLVNSYH LLLCCLDLIF ANAIMCPNRR DLLNPSFKGL PSDFHAPDFK AAEEPPCIIA VLCDLHDGLL VEAKGIKEHY FKPYISKLFD KKILKGECLL DLSSFTDNSK AVNKEYEEYV LTVGDFDERI FLGADAEEEI GTPRKFTADT PFGKLTSQAS VECNLQQHFE KKRSFAPSTP LTGRRYLQEK EAVTTPVASA TQSVSRLQSI VAGLKSAPSE QLLNIFESCM RNPMGNIIKI VKGIGETFCQ HYTQSTDKQP GSHIDFAVNR LKLAEILYYK ILETIMVQET RRLHGMDMSV LLEQDIFHKS LMACCLEIVL FAYSSPRTFP WIIEVLDLQP FYFYKVIEVV IRSEEGLSRD MVKHLNSIEE QILESLAWTN NSALWEALHA SANRVPSCEE VIFPNNFEIG NGGNVQGHLP MMPMSPIIHP RVKEVRTDSG SLRQDMQPLS PISVHERYSS PAAGSAKRRL FGDDPPKDTL MDKIMAEGTK LKIAPSSVTA ESLSISPGQA LLTMATTTVT GTTGRKVTVP LHGIANDAGE ITLVPISMNP TQESTAESPV SLTAQSLIGT SPKQTHLTKA QDAHLTGVSK PKRTGSLALF YRKVYHLASV RLRDLCLKLD VSNELRRKIW TCFEFTLVHC PDLMKDRHLD QLLLCAFYIM AKVTKEERTF QEIMKSYRNQ PQANSHVYRS VLLKSIPGGV VVYNGDCEMT DGDIEDATKT PNCSSEPVKE ERGDLIKFYN TVYVGRVKSF ALKYDLSNQD HIMDAPPLSP FPHIKQQPGS PRRISQQHSL YVSPHKNGAG LTPRSALLYK FNGSPSKSLK DINNMIRQGE QKTKKRVIAI SGDADSPAKR LCQENDDVLL KRLQDVVSER ANH
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. May act as a tumor suppressor.

Gene References into Functions

the transcriptional corepressor p107 orchestrates a metabolic checkpoint that determines adipocyte lineage fates for non-committed progenitors. PMID:28233396
p107 is required for the efficient recruitment of an activating SWI/SNF chromatin-remodeling complex, an essential event in Alpl induction. PMID:25182511
while p107 alone did not have an essential role in islet homeostasis, when combined with Rb deletion, its absence potentiated apoptosis of both alpha and beta cells resulting in glucose intolerance and diminished islet mass with ageing PMID:25249236
Findings indicate that retinoblastoma-like protein p107 expression in stem cells commits cells to the white versus brown adipose lineage. PMID:24449206
p107 retinoblastoma protein is regulated by Cdk6/Ccnd1 in growth plates. PMID:23803733
Cell cycle assays further indicated that activation of p107 transcription during S phase through the two E2F binding sites was critical for controlled cell cycle progression. PMID:20585628
p107 and p130 Coordinately regulate proliferation, Cbfa1 expression, and hypertrophic differentiation during endochondral bone development PMID:12086466
p107 and p130, but not pRb, are critical effectors of FGF-mediated growth inhibition in chondrocytes. PMID:12177046
regulation of p107 and p130 expression during adipocyte differentiation with/without inhibition of MEK PMID:12242027
impaired terminal differentiation in the interfollicular keratinocytes of p107/p130-double-null mice epidermis PMID:12702649
the pRb family member p107 is not a key regulator in vascular injury response. PMID:12860570
Autorepression of c-myc requires initiator, E2F-binding site elements and p107. PMID:14716294
p107 binds to cyclin A47 when p21 and p27 are absent. PMID:15070741
p107 regulates neural precursor cells in the mouse brain. PMID:15353549
in a variety of tissues tumor development by loss of pRB is suppressed by its homologs p107 and p130 PMID:15574596
Data suggest that p107, in addition to its interaction with E2F, inhibits cell proliferation through the control of Skp2 expression and the resulting stabilization of p27. PMID:15631990
The Rbl1 protein shows a marked genomic instability, which is coincidental with decreased DNA methylation, increased acetylation of histone H3 and decreased tri-methylation of histone H4 at lysine 20 (H4K20). PMID:15750587
loss of pRb and p107 or p130 together produced chronic hyperplasia and dysplasia of the small intestinal and colonic epithelium PMID:16258171
These results demonstrate that p27 carries out overlapping functions with p107 in controlling cell cycle exit during chondrocyte maturation. PMID:17502351
p107 regulates the rate of progenitor commitment to a neuronal fate. PMID:17591923
data demonstrate that p107 behaves as a tumor suppressor in epidermis in the absence of pRb and suggest novel tumor-suppressive roles for p107 in the context of functional p53 and activated Ras PMID:17932945
along with Rb, and p130 maintains hematopoietic stem cells quiescence and the balance between lymphoid and myeloid cell lineages PMID:18940733
These results support a model whereby p107/E2F3 regulates the pool of FGF-responsive progenitors by directly regulating FGF2 gene expression in vivo. PMID:19564414

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Subcellular Location

Nucleus.

Protein Families

Retinoblastoma protein (RB) family

Tissue Specificity

Highly expressed in fetal heart and liver. Expressed at low levels in all other fetal tissues except skeletal muscle. High levels in neonatal spleen and thymus with low levels in other tissues. In adult, highly expressed in testis. Barely detectable in ot

Database Links

UNIGENE: Mm.244671

KEGG: mmu:19650

STRING: 10090.ENSMUSP00000029170

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