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Recombinant Mouse Receptor-type tyrosine-protein phosphatase R (Ptprr), partial

Recombinant Mouse Receptor-type tyrosine-protein phosphatase R (Ptprr), partial

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MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Ptprr

Purity

>85% (SDS-PAGE)

Target Names

Ptprr

Uniprot NO.

Q62132

Alternative Names

Ptprr; Ptp13; Receptor-type tyrosine-protein phosphatase R; R-PTP-R; EC 3.1.3.48; Phosphotyrosine phosphatase 13; Protein-tyrosine-phosphatase SL

Species

Mus musculus (Mouse)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus. Isoform gamma may have a role in patterning and cellular proliferation of skeletal elements in the precartilaginous/cartilaginous skeleton.

Gene References into Functions

These findings indicate an important role for PTPRR in maintaining low basal mitogen-activated protein kinase activity in Purkinje cells. PMID:25571783
The data of this study disclosed a distinct role for PTPRR in recognition memory and exploration of a new environment. PMID:24556203
Results support the suggested link between PTPRR isoforms and cerebellar calcium ion homeostasis, and suggest an additional role in the process of cell-cell adhesion PMID:21850207
Multiple isoforms through the use of distinct promoters, alternative splicing and differential translation starts. PMID:15461663
The ERK2 docking groove is more restrictive and selective for its tyrosine phosphatase inactivators than for MEK1/2 and indicate that distinct ERK2 residues modulate the docking interactions with activating and inactivating effectors. PMID:16148006
PTPBR7, was subject to N-terminal proteolytic processing, in between amino acid position 136 and 137, resulting in an additional, 65-kDa transmembrane PTPRR isoform. PMID:17147696
Ptprr-/- mice displayed ataxia characterized by defects in fine motor coordination and balance skills. PMID:17266727
PTP-SL, like PTPBR7, is a single membrane-spanning receptor-type protein tyrosine phosphatases. PMID:18068678

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Subcellular Location

[Isoform Alpha]: Cell membrane; Single-pass type I membrane protein.; [Isoform Beta]: Cytoplasm. Note=Locates to the areas within the cytoplasm.; [Isoform Gamma]: Cytoplasm. Note=Locates to the areas within the cytoplasm.

Protein Families

Protein-tyrosine phosphatase family, Receptor class 7 subfamily

Tissue Specificity

Expressed in the heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. Isoform alpha is expressed throughout the granular layer of the cerebellar but not within the Purkinje cells, also in the villi of the ileum and jejunum and both the v

Database Links

UNIGENE: Mm.336316

KEGG: mmu:19279

STRING: 10090.ENSMUSP00000064392

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