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Recombinant Mouse Ras-related protein Rap-1b (Rap1b)

Recombinant Mouse Ras-related protein Rap-1b (Rap1b)

Code
MSDS	MSDS
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Rap1b

Uniprot NO.

Q99JI6

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-181

Target Protein Sequence

MREYKLVVLG SGGVGKSALT VQFVQGIFVE KYDPTIEDSY RKQVEVDAQQ CMLEILDTAG TEQFTAMRDL YMKNGQGFAL VYSITAQSTF NDLQDLREQI LRVKDTDDVP MILVGNKCDL EDERVVGKEQ GQNLARQWNN CAFLESSAKS KINVNEIFYD LVRQINRKTP VPGKARKKSS C

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Description

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Target Background

Function

GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function.

Gene References into Functions

findings reveal key roles for the bidirectional synaptic expression of the Rap1b small GTPase and an associated local synaptic protein translation network in this process. PMID:26844834
Rap1b deficiency promoted the transcellular route of diapedesis through endothelial cell. Increased transcellular migration of Rap1b-deficient neutrophils in vitro was selectively mediated by enhanced PI3K-Akt activation and invadopodia-like protrusions. PMID:25092872
Rap1b in both smooth muscle and endothelium plays a key role in maintaining blood pressure by controlling normal vascular tone. PMID:24790136
two different activation mechanisms of Rap1b as well as novel functions of Rap1b in platelet secretion and in integrin alpha(IIb)beta(3) outside-in signaling. PMID:21940635
Rap1b-dependent VEGF-VEGFR2 activation is in part mediated via integrin alpha(v)beta(3). PMID:21636859
Upon activation, Rap1b colocalized with the scaffolding protein IQGAP1. PMID:20733035
Rap1b is oncogenic in the thyroid in ways linked to transduction of the cAMP mitogenic signal PMID:15331589
Data provide genetic evidence that Rap1b is involved in a common pathway of integrin activation, is required for normal hemostasis in vivo, and may be a clinically relevant antithrombotic therapy target. PMID:15696195
These studies provide evidence that Rap1b is required for normal angiogenesis and reveal a novel role of Rap1 in regulation of proangiogenic signaling in endothelial cells. PMID:17993608
Rap1b-mediated suppression of synaptic transmission enables plasticity in the cortico-amygdala pathway, which is required for fear learning with a moderately aversive unconditional stimulus. PMID:18305243
Rap1b-deficient B cells had impaired adhesion and reduced chemotaxis in vitro, and lessened homing to lymph nodes in vivo PMID:18319399
Rap1b is the dominant isoform in B cells and regulates cell proliferation, cell adhesion, T-dependent humoral responses, cell migration in B cells. PMID:18714009
Rap1b ameliorates glucose-induced mitochondrial dysfunction in renal tubular cells PMID:18753253
Rap1b is required for maximal GPVI-induced but not ADP-induced activation of alpha2beta1 in murine platelets. PMID:19192113