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Recombinant Mouse Ras GTPase-activating-like protein IQGAP2 (Iqgap2), partial

Recombinant Mouse Ras GTPase-activating-like protein IQGAP2 (Iqgap2), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Iqgap2

Purity

>85% (SDS-PAGE)

Target Names

Iqgap2

Uniprot NO.

Q3UQ44

Alternative Names

Iqgap2Ras GTPase-activating-like protein IQGAP2

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

2-1575

Target Protein Sequence

PHEELPSLQ RPRYGSIVDD ERLSAEEMDE RRRQNIAYEY LCHLEEAKRW MEVCLVEELP PTTELEEGLR NGVYLAKLAK FFAPKMVSEK KIYDVEQTRY KKSGLHFRHT DNTVQWLRAM EAIGLPKIFY PETTDVYDRK NIPRMIYCIH ALSLYLFKLG IAPQIQDLLG KVDFTEEEIS NMRKELEKYG IQMPAFSKIG GILANELSVD EAALHAAVIA INEAIEKGVA KQTIITLRNP NAVLTCVDDS LSQEYQKELW EAKKKKEESA KLKNSCISEE ERDAYEELLT QAEIQSNIST VNRMAAVDHI NAVLQEGDPE NTLLALKKPE AQLPAVYPFA AVMYQNELFN LQKQNTSNYL AHEELLIAVE MLSAVALLNQ ALESSDLVAV QNQLRSPTIG FNNLDEAHVD RYADALLSVK QEALSQGQDT LSWNEIQNCI DMINNQIQEE NDRMVVLGYI NEAIDAGNPL KTLDTLLLPT ANIRDVDPDC AQHYQDVLFY TKSQKLGDPK NVSKVLWLDE IQQAINEANV DENRAKQWVT LVVDVNECLD RKQSDHILTA LKSSPSNIHN ILPECANKYY DTLVKAKESK TDNESSEGSW VTLNVQEKYN YYYNTDSKEG SWVPPELCLS KESWLTGEEI EDIVEEVTSD YIREKLWSAS EDLLVRFEAT TLGPALREEF EARKAFLYEQ TESVVKIQAF WKGFKQRQEY LHRQQVFAGN VDSVVKIQSW FRMVTARKSY LSRLRYFEDH KNEIVKIQSL LRASKARDDY KALVGSENPP LTVIRKFVYL LDQSDLDFQE ELEVARLREE VVTKIRANQQ LEKDLNLMDI KIGLLVKNRI TLEDVISHRK KLNKKKGGEI EILNNTDNKG IKSLSKERRK TLETYQQLFY LLQTKPSYLA KLIFQMPQNK STKFMDTVIF TLYNYASNQR EEYLLLKLFK TALEEEIKSK VDQVQDIVTG NPTVIKMVVS FNRGARGQNT LRQLLAPVVK EIIEDKALVI NTNPVEVYKA WVNQLETQTG EASKLPYDVT TEQALTYPEV KNKLEASIEN LRKVTDKVLG SIISSLDLLP YGLRYIAKVL KNSIREKFPD ATEEELLKIV GNLLYYRYMN PAIVAPDGFD IIDMTAGGQI NSNQRRNLGS VAKVLQHAAS NKLFEGENEH LSSMNNYLSE TYQEFRKYFQ EACDVPEPEE KFNMDKYTDL VTVSKPVIYI SIEEIINTHL LLLEHQDAIA TEKSDLLNEL LESLGEVPTV ESFLGEGAVD PNDPNKENTL NQLSKTEISL SLTSKYDVKD GEAVDGRSLM IKTKKLIIDV TRNQPGSTLT EILETPATGQ QELEHAKDME SRAVVDSRTP EEGKQSQAVI EDARLPLEQK KRKIQRNLRT LEQTGHVSSK NKYQDILNEI AKDIRNQRIH RKLRKAELSK LQQTLNALNK KAAFYEDQIN YYDTYIKTCV DNLKRKNSRR SIKLDGKAEP KGTKRVKPVR YTAAKLHDKG VLLGIDDLQT NQFKNVMFDI IATEDMGIFD VRSKFLGVEM EKVQLNIQDL LQMQYEGVAV MKMFDKVKVN VNLLIYLLNK KFYGK
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.

Gene References into Functions

The exacerbated mast cell responses observed in the absence of Dnmt3a were recapitulated or enhanced by treatment with the demethylating agent 5-aza-2'-deoxycytidine as well as by down-modulation of Dnmt1 expression. These effects were in part mediated by the dysregulated expression of the scaffold protein IQGAP2. PMID:28167789
found a hypomethylated region mapping to Iqgap2 (IQ motif-containing GTPase activating protein 2) and F2rl2 PMID:28179424
Data show that complete loss of IQ motif-containing GTPase-activating protein 2 (IQGAP2) gene leads to protection from dextran sulfate sodium (DSS)-induced colitis. PMID:26047140
Transcript profiling identifies iqgap2(-/-) mouse as a model for advanced human hepatocellular carcinoma. PMID:23951254
murine IQGAP2 selectively regulates the facilitated phase of hepatic fatty acid uptake both in vitro and in vivo PMID:21968151
Development of hepatocellular carcinoma in Iqgap2-deficient mice is Iqgap1 dependent. PMID:18180285