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Recombinant Mouse E3 ubiquitin-protein ligase RNF43 (Rnf43), partial

Recombinant Mouse E3 ubiquitin-protein ligase RNF43 (Rnf43), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details

Abbreviation

Rnf43

Purity

>85% (SDS-PAGE)

Target Names

Rnf43

Uniprot NO.

Q5NCP0

Alternative Names

Rnf43; E3 ubiquitin-protein ligase RNF43; EC 2.3.2.27; RING finger protein 43; RING-type E3 ubiquitin transferase RNF43

Species

Mus musculus (Mouse)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Along with RSPO2 and ZNRF3, constitutes a master switch that governs limb specification.

Gene References into Functions

RNF43 and ZNRF3 reduce Wnt signals by selectively ubiquitinating frizzled receptors, thereby targeting these Wnt receptors for degradation PMID:22895187

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Subcellular Location

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Nucleus envelope.

Protein Families

ZNRF3 family

Tissue Specificity

Expressed in crypt base columnar cells of small intestinal epithelium. Crypt base columnar cells are small cycling cells residing between the terminally differentiated Paneth cells at crypt bottoms. Colocalizes with Lgr5-positive stem cells.

Database Links

UNIGENE: Mm.440230

KEGG: mmu:207742

STRING: 10090.ENSMUSP00000090476

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