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Recombinant Mouse Putative Polycomb group protein ASXL2 (Asxl2), partial

Recombinant Mouse Putative Polycomb group protein ASXL2 (Asxl2), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Asxl2

Purity

>85% (SDS-PAGE)

Target Names

Asxl2

Uniprot NO.

Q8BZ32

Alternative Names

Asxl2; Kiaa1685Putative Polycomb group protein ASXL2; Additional sex combs-like protein 2

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-1370

Target Protein Sequence

MREKGRRKKG RTWAEAAKTV LEKYPNTPMS HKEILQVIQR EGLKEIRSGT SPLACLNAML HTNSRGEEGI FYKVPGRMGV YTLKKDVPDG VKELSECSEE SSDGQSDSHS SDNSSSSDGG SNKEGRKSRW KRKVSSRLSH PPSPPSGCPS PTIPASKVIS PSQKHSKKAL KQALKQQQQK KKQQQCRPSM SISNQHLSLK TVKAASDSVP AKPGQMKRTK CADIDVETPD SILVNTNLRA LINKHTFSVL PGDCQQRLLL LLPEVDRQVG PDGLMKLNGS ALNNEFFTSA AQGWKERLSE GEFTPEMQVR IRQEIEKEKK VELWKEQFFE NYYGQSSGLS LEDSQKLTAS SSDPKAKKTP AEQPKSILPS EASPVRIVPV VPQSECKEEA VQIPSPSQKE ENQDEARPDS KSPEPVLASA SNTNELITMK PIKSPKDEGL LEQKPVACAE QESEKENHVT TTSRNNKSEN QEALAISPSK SKNAGLQKPI IKPVAEASPL NPDMKMPPAT VTDQIQESLK RKSSLTDEEA TSSWEKRPRI TENRQHQQPF QVSPQPFLNR GDRVQVRKVP PLKIPVSRIS PMLFSTSQVS PRARFPISIT SPYRTGARTL ADIKAKAQLV EAQKAAAAAA AAAAAAASVG GTIPGPGPGG GQSPREGGER KIAGGGSAGS DPVSTNGKGP TLELAGTGSR GGTRELLPCG PQPETNMPGQ AQPPGISGAQ LQQTSSVPTG LASSGACTSV PLPAHIEISN SEKPNLHKAT ATAASPCHLQ DPRSCRLEKA LSPTGPPLIS GASTVYFVAD GTVEPKAGSN KNAPKPSALA KTTAPAPLDM TSSPVTTASL EKLPVPQISG TATSTGSAPS SSTLPAASSL KTPGTSANMN GPISRTSSSI PANNPLVTQL LQGKDVPLEQ ILPKPLTKIE MKTVPLTTKE EKGIGIFPGI SVMESSSREE VNGRQAHLAI PQLGKPLQSK QLSQVPRPVF TAKDRKDPCI DTHQYREGLS KTTQDQLFQT LIQRAQRQSV LSFVPPSQFN FAHSGFHLED ISTSQKFMLG FAGRRTSKPA MAGHYLLNIS TYGRGTENIK RTHSVNPDDR FCLSSPTEAL RMGHADYKNT TGEISSKEDE SDEDRVGDEQ EPISVKEEPW ASQSSGRHPH HGEASSTNDC LASKNGKTEA PVSEQTTLGQ ENYIFSRGQA SDEKSLPRDF IPAAHKQMTH AVRGKTVCSS PELFNSTALS LPADSPTHQP LLLPPLQTPK LYGSPTQIGP SYRGMINVST SSDMDHNSAI PGSQVSSNVG DVMSFSVTVT TIPASQAMNP SSHGQTIPVQ TFPDDNSIED TPSKCYCRLK AMIMCKGCGA FCHDDCIGPS KLCVSCLVVR
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility. Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator for PPARG and enhances its adipocyte differentiation-inducing activity; the function seems to involve differential recruitment of acetylated and methylated histone H3.

Gene References into Functions

ASXL2 functions as a tumour suppressor to maintain normal Hematopoietic stem cell function. PMID:28593990
ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia. PMID:28516957
ASXL2 is a master regulator of skeletal, lipid, and glucose homeostasis PMID:26051940
Asxl2-/- neonates have patent ductus arteriosus and consequent lung hemorrhage and die soon after birth. PMID:24860998
ASXL2 and WTIP are expressed in mouse embryonic epicardial cells. ASXL2 and WTIP participate in regulation of retinoic acid signaling during heart development. PMID:25065743
ASXL2 and PRC2 interact in the adult heart and co-localize to target promoters. PMID:24040135
Chromatin factors like Asxl2 function in the adult heart to regulate cell type- and stage-specific patterns of gene expression. PMID:23046516
the knockdown of Asxl2 in bone marrow macrophages impaired their ability to form osteoclasts. PMID:21490954