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Recombinant Mouse Protein unc-13 homolog A (Unc13a), partial

Recombinant Mouse Protein unc-13 homolog A (Unc13a), partial

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MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Unc13a

Purity

>85% (SDS-PAGE)

Target Names

Unc13a

Uniprot NO.

Q4KUS2

Alternative Names

Unc13a; Protein unc-13 homolog A; Munc13-1

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-1712

Target Protein Sequence

MSLLCVGVKK AKFDGAQEKF NTYVTLKVQN VKSTTIAVRG SQPSWEQDFM FEINRLDLGL TVEVWNKGLI WDTMVGTVWI PLRTIRQSNE EGPGEWLTLD SQAIMADSEI CGTKDPTFHR ILLDAHFELP LDIPEEEARY WAKKLEQLNA MRDQDEYSFQ DQQDKPLPVP SSQCCNWNYF GWGEQNDDPD SAVDDRDSDY RSETSNSIPP PYYTTSQPNA SVHQYSVRPP PLGSRESYSD SMHSYEEFSE PRALSPTGSS RYASSGELSQ GSSQLSEDFD PDEHSLQGSE LDDERDRDSY HSCHSSVSYH KDSPRWDQDD EDLEDLEDLE DEELPEEEEE LEEEGEEELE EEDLEEEEEV PDDLASYTQQ EDTTVAEPKE FKRISFPTAA PQKDDKVSAV PTEAPEVAKG IPKAATPEEK AAAERAQEAE PPKSEESFRS REEEEGQEGQ DAMSRAKANW LRAFNKVRMQ LQEARGEGDM SKSLWFKGGP GGGLIIIDSM PDIRKRKPIP LVSDLAMSLV QSRKAGITSA LASSTLNNEE LKNHVYKKTL QALIYPISCT TPHNFEVWTA TTPTYCYECE GLLWGIARQG MRCTECGVKC HEKCQDLLNA DCLQRAAEKS SKHGAEDRTQ NIIMVLKDRM KIRERNKPEI FELIQEIFAV TKSAHTQQMK AVKQSVLDGT SKWSAKISIT VVCAQGLQAK DKTGSSDPYV TVQVGKTKKR TKTIYGNLNP VWEENFHFEC HNSSDRIKVR VWDEDDDIKS RVKQRFKRES DDFLGQTIIE VRTLSGEMDV WYNLDKRTDK SAVSGAIRLH ISVEIKGEEK VAPYHVQYTC LHENLFHFVT DVQNNGVVKI PDAKGDDAWK VYYDETAQEI VDEFAMRYGV ESIYQAMTHF ACLSSKYMCP GVPAVMSTLL ANINAYYAHT TASTNVSASD RFAASNFGKE RFVKLLDQLH NSLRIDLSMY RNNFPASSPE RLQDLKSTVD LLTSITFFRM KVQELQSPPR ASQVVKDCVK ACLNSTYEYI FNNCHELYGR EYQTDPAKKG EVPPEEQGPS IKNLDFWSKL ITLIVSIIEE DKNSYTPCLN QFPQELNVGK ISAEVMWSLF AQDMKYAMEE HDKHRLCKSA DYMNLHFKVK WLYNEYVAEL PTFKDRVPEY PAWFEPFVIQ WLDENEEVSR DFLHGALERD KKDGFQQTSE HALFSCSVVD VFSQLNQSFE IIKKLECPDP QIVGHYMRRF AKTISNVLLQ YADIVSKDFA SYCSKEKEKV PCILMNNTQQ LRVQLEKMFE AMGGKELDAE ASGTLKELQV KLNNVLDELS HVFATSFQPH IEECVRQMGD ILSQVKGTGN VPASACSSVA QDADNVLQPI MDLLDSNLTL FAKICEKTVL KRVLKELWKL VMNTMEKTIV LPPLTDQTMI GTLLRKHGKG LEKGRVKLPS HSDGTQMIFN AAKELGQLSK LKDHMVREEA KSLTPKQCAV VELALDTIKQ YFHAGGVGLK KTFLEKSPDL QSLRYALSLY TQATDLLIKT FVQTQSAQGS GVEDPVGEVS VHVELFTHPG TGEQKVTVKV VAANDLKWQT SGIFRPFIEV NIVGPQLSDK KRKFATKSKN NSWAPKYNES FQFSLSADAG PECYELQVCV KDYCFAREDR TVGLAVLQLR ELAQRGSAAC WLPLGRRIHM DDTGLTVLRI LSQRSNDEVA KEFVKLKSDT RSAEEGGAAP AP
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. Facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release. Also involved in secretory granule priming in insulin secretion. Plays a role in dendrite formation by melanocytes.

Gene References into Functions

Data suggest that the Munc13-1/2 heterodimer is an active component of the vesicle docking, priming and release complex. PMID:28489077
Synaptic UNC13A protein variant causes increased neurotransmission and dyskinetic movement disorder PMID:28192369
CAPS1 binds to the full-length of cytoplasmic syntaxin-1 with preference to its "open" conformation, whereas Munc13-1 binds to the first 80 N-terminal residues of syntaxin-1. PMID:23801330
Rab37 interacts with Munc13-1 to control TNF-alpha secretion from activated macrophages PMID:21805469
These results indicate that synaptic vesicle docking at the plasma membrane and functional priming are respective morphological and physiological manifestations of the same molecular process mediated by SNARE complexes and Munc13-1/2s. PMID:19558619

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Subcellular Location

Cytoplasm. Cell membrane; Peripheral membrane protein. Cell junction, synapse, presynaptic cell membrane; Peripheral membrane protein. Cell junction, synapse, presynaptic active zone.

Database Links

UNIGENE: Mm.334606

KEGG: mmu:382018

STRING: 10090.ENSMUSP00000030170

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