Recombinant Mouse Protein jagged-2 (Jag2), partial

1. A deficiency of KLF2 increased the expression of Notch ligand Jagged2 via hypoxia-inducible factor 1alpha (HIF-1alpha), which led to Th2 amplification. PMID:27302755
2. these findings suggest that Jagged2 signaling can affect graft acceptance by upregulation of IL-6 and consequent resistance to Treg-cell suppression. PMID:23526606
3. results demonstrate that maternal P4 levels during midpregnancy can inhibit the expression of Jagged2 and Notch1, which are involved in primordial folliculogenesis, in the mouse fetal ovary PMID:22652674
4. These data suggest that Notch ligands are differentially regulated in DCs: Delta-like 4 is regulated by T helper cells and by pathogen-derived Th1 stimuli, whereas Jagged 2 is regulated by Th2 cells and pathogen-derived Th2-promoting stimuli. PMID:21352254
5. novel Jagged2/miR-200-dependent pathway that mediates lung adenocarcinoma epithelial-to-mesenchymal transition and metastasis PMID:21403400
6. Loss of Jagged2 is associated with craniofacial, limb, and T cell development. PMID:20533406
7. identification as substrated for presenilin-dependent gamma-secretase cleavage PMID:12551931
8. Jagged2 stimulates the development of natural killer cells from Lin(-) Sca-1(+) c-kit(+) hematopoietic stem cells PMID:15650053
9. DLL1, functions synergistically with JAG2 in regulating hair cell differentiation in the cochlea. PMID:16141228
10. both Notch1 and 2 are required in the ectoderm to receive the Jagged2 signal; Notch receives this signal at an early stage in the developmental process and memory of this event is retained by the mesenchyme PMID:16169548
11. Notch signalling, involving Notch1 and Jagged2 is required to regulate the number of Fgf8-expressing cells that comprise the apical ectodermal ridge, and this is important for the freeing of the digits during normal limb formation. PMID:16245338
12. Jag2-Notch1 signaling is spatiotemporally regulated in the oral epithelia during palate development to prevent premature palatal shelf adhesion to other oral tissues and to facilitate normal adhesion between the elevated palatal shelves. PMID:16607638
13. p63, and particularly the DeltaNp63 isoform, is essential for thymic development via enhanced expression of FgfR2 and Jag2. PMID:17626181
14. Results suggest that Jagged2 plays an essential role for mandibular condylar cartilage morphogenesis and development. PMID:18226989
15. jagged2 is not fundamentally required for Th2 induction by soluble egg antigen-activated dendritic cells in vivo PMID:18350543
16. These results indicate that the Jagged2-Notch axis plays a crucial role in DC-mediated natural killer cell cytotoxicity. PMID:18458347
17. Jagged 2 expression by dendritic cells is not sufficient or required for T helper (Th) type 2 cell differentiation. PMID:18523256
18. mesenchymal stem cells, partly via cell-cell contact, drive mature dendritic cells to differentiate into a novel Jagged-2-dependent regulatory DC population and escape their apoptotic fate PMID:18832657
19. Results suggest that the Notch1 signaling pathway through Jagged2 could be importantly related to Math1, directing the process of odontogenesis toward cell differentiation. PMID:19181188
20. Jagged2 are Expressed in the developing mouse eye and in differentiating neurons. PMID:19191219
21. IRF6 and Jagged2 is essential for controlling palatal adhesion. PMID:19439425

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UNIGENE: Mm.186146

KEGG: mmu:16450

STRING: 10090.ENSMUSP00000075224