Recombinant Mouse Protein fosB (Fosb)

1. Fosb-targeted histone acetylation in D2-MSNs or histone methylation in D1-MSNs promotes a stress-susceptible, depressive-like phenotype, while histone methylation in D2-MSNs or histone acetylation in D1-MSNs increases resilience to social stress as quantified by social interaction behavior and sucrose preference. PMID:28462942
2. study provides key insights into functional domains regulated by FosB in the hippocampus, emphasizing remarkably different programs of gene regulation under physiological and pathological conditions PMID:29408867
3. These findings suggest that GosB may regulate mammary epithelial cells milk fat synthesis and apoptosis via PPARgamma in mouse mammary glands. PMID:29181403
4. Study investigated effects of chronic variable mild stress (CVMS) in non-injected, vehicle and imipramine-treated KO mice vs. wildtype (WT) counterparts and mapped the CVMS-related FosB response in 18 brain areas; found that PACAP deficiency affects neuronal reactivity in a brain area-specific manner in stress centers PMID:27282087
5. abnormal regulation of MSK1 contributes to the development of L-DOPA-induced dyskinesia and to the concomitant increase in striatal FosB, which may occur via increased histone H3 phosphorylation at the fosB promoter PMID:25193242
6. The most highly stereotypic mice showed the most elevated FosB/DeltaFosB activity in the nucleus accumbens PMID:26731014
7. FosB/DeltaFosB immunoreactivity was transiently increased in hippocampus and parahippocampal cortices by 6-Hz corneal stimulation. FosB induction was primarily localized in pyramidal neurons. PMID:26555229
8. This study demonstrate that the DeltaFosB is induced in the hippocampus by learning, regulates the shape of hippocampal synapses, and is required for memory formation, opening up a host of new possibilities for hippocampal transcriptional regulation. PMID:26446228
9. These findings confirm the unique role of DeltaFosB in the nucleus accumbens in controlling responses to drugs of abuse and stress. PMID:25313003
10. D1Rs play a major role in THC-mediated DeltaFosB induction. PMID:26099530
11. Histone methylation or acetylation at the Fosb locus in nucleus accumbens, was sufficient to control drug- and stress-evoked behavioral responses. PMID:25347353
12. These results indicate that social stress-induced behavioral deficits are mediated partly by molecular adaptations in mPFC involving DeltaFosB and CCK through cortical projections to distinct subcortical targets. PMID:24623766
13. Fosb expression significantly increased corresponding to the DNA methylation level of the gene body in the arsenic-exposed group. PMID:24118411
14. Cytisine modulates chronic voluntary ethanol consumption and reduces ethanol-induced up-regulation of striatal DeltaFosB. PMID:23601929
15. This study demonistrated that the fosB-null mouse is the first animal model to provide a genetic and molecular basis for the comorbidity between depression and epilepsy with abnormal neurogenesis, all of which are caused by loss of a single gene, fosB. PMID:23303048
16. Chronic self-administration of alcohol results in elevated DeltaFosB in brain region and genotype specific of mice. PMID:23102405
17. This study demonistrated that in transgenic mice overexpressing DeltaFosB to show that this genetic manipulation enhances the rewarding effects of cocaine. PMID:21962331
18. These findings indicate that FosB is essential for stress tolerance mediated by delta-FosB. PMID:21679928
19. These results suggest that DeltaFosB signaling in nucleus accumbens mediates adaptive responses to calorie restriction. PMID:21215388
20. transcription factor FosB/activating protein-1 (AP-1) activation is a prominent downstream signal of the extracellular nucleotide receptor P2RX7 in monocytic and osteoblastic cells PMID:20813842
21. FosB is involved in thermoregulation-independent protective functions against methamphetamine neurotoxicity in postsynaptic neurons. PMID:19890265
22. study found DeltaFosB mediates an essential mechanism of resilience; induction of DeltaFosB in nucleus accumbens was both necessary & sufficient for resilience & for fluoxetine to reverse behavioral pathology induced by social defeat PMID:20473292
23. In both light and dark phases of the daily cycle, maternal stimulation of DBA/2J mothers following return of their pups evokes an increase in FosB-immunoreactivity in the medial preoptic nucleus. PMID:12376177
24. Results suggest that the changes in osteoblast and adipocyte differentiation in DeltaFosB transgenic mice result from independent cell-autonomous mechanisms. PMID:15024071
25. Permanent elimination of fosB gene products does not alter ethanol intake but may enhance preference for sweet solutions in mice. PMID:15276803
26. Enhanced MMP-2 transcription and translation following I/R injury are mediated by induction, via oxidant stress, of discrete AP-1 transcription factor components, JunB and FosB. PMID:16699069
27. Lipopolysaccharide-induced depressive-like behavior was associated with delayed cellular activity assessed by FosB/DeltaFosB immunostaining within the extended amygdala, hippocampus and hypothalamus. PMID:17482371
28. Results indicate that inescapable stress-induced accumulation of deltaFosB in the ventrolateral periaqueductal gray desensitizes substance P neurons enriched in this area and opposes behavioral despair by promoting active defense responses. PMID:17640529
29. These results suggest the pivotal role of ERK-FosB signaling in the initiation of parental care. PMID:17707653
30. Mice lacking fosB are less sensitive to rewarding properties of morphine and display spatial memory impairment; results suggest involvement of fosB and its proteins in motivational aspects of reinforcers as well as in learning and memory processes. PMID:18407360
31. DeltaFosB's AP-1 transactivating function is not needed to induce increased bone formation, and Delta2DeltaFosB may act, at least in part, by increasing Smad1 expression, phosphorylation, and translocation to the nucleus PMID:18433296
32. Primary osteoblasts overexpressing Delta2Deltafosb protein formed more nodus than the control cells. PMID:18630601
33. FosB negatively regulates cell-matrix adhesion and the TGF-beta1 signaling pathway. PMID:18753407
34. This study demonstrated that elevation of DeltaFosB not only increases the reward value of drug, but the reward value of the saccharin cue as well. PMID:19331462

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UNIGENE: Mm.248335

KEGG: mmu:14282

STRING: 10090.ENSMUSP00000003640