Recombinant Mouse Protein boule-like (Boll)

Code
MSDS	MSDS
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Boll

Uniprot NO.

Q924M5

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-281

Target Protein Sequence

MQTDSLSPSP NPVSPVPLNN PTSGPRYGTV IPNRIFVGGI DFKTNENDLR KFFSQYGSVK EVKIVNDRAG VSKGYGFITF ETQEDAQKIL QEAEKLNYKD KKLNIGPAIR KQQVGIPRSS LMPAAGTMYL TTSTGYPYTY HNGVAYFHTP EVTSVPPSWP SRSISSSPVM VAQPVYQQPA YHYQAPAQCL PGQWQWGVPQ SPASSAPFLY LQPSEVIYQP VEIAQDGGCV PPPLSLMETS VPEPYSDHGV QAAYHQVYAS SAIAMPAPMM QPEPIKVRSL F

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Description

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Target Background

Function

Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation.

Gene References into Functions

asked whether BOULE, the founding member of DAZ family proteins, is a component of the SGs. We show that BOULE is recruited to the SGs upon heat stress, and that these SGs are developmental stage-specific PMID:27632217
These results showed that IGF1 regulated the expression of BOULE and CDC25A mRNAs via ERK1/2 signaling and in T-independent pathway during spermatogenesis in the adult mouse testes. PMID:25726377
demonstrate that Boll is also transiently expressed during oogenesis in the fetal mouse ovary, but is simultaneously co-expressed within the same germ cells as Dazl PMID:24086306
Expression of key regulators of spermiogenesis was unaffected in Boule(-/-) mice, suggesting that Boule regulates germ-cell differentiation through a novel pathway. PMID:20335278

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Subcellular Location

Cytoplasm.

Protein Families

RRM DAZ family

Tissue Specificity

Testis specific. Not expressed in early embryos, primoridal germ cells and spermatogonial cells. First expressed in the cytoplasm of spermatocytes and then persists through meiosis.

Database Links

UNIGENE: Mm.483408

KEGG: mmu:75388

STRING: 10090.ENSMUSP00000084868

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