Recombinant Mouse Protein Wnt-16 (Wnt16)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Target Background

Product Details

Abbreviation

Wnt16

Purity

>85% (SDS-PAGE)

Target Names

Wnt16

Uniprot NO.

Q9QYS1

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

30-364

Target Protein Sequence

N WMWLGIASFG VPEKLGCADL PLNSRQKELC KRKPYLLPSI REGARLGIQE CRSQFRHERW NCMVATTTST QLATAPLFGY ELSSGTKETA FIYAIMAAGL VHSVTRSCSA GNMTECSCDT TLQNGGSPSE GWHWGGCSDD VQYGMWFSRK FLDLPIRNTT GKESRVLLAM NLHNNEAGRQ AVAKLMSVDC RCHGVSGSCA VKTCWKTMSS FEKIGHFLKD KYENSIQISD KTKRKMRRRE KDQRQTPILK DDLLYVHKSP NYCVENKKLG IPGTQGRECN RTSGGADGCN LLCCGRGYNT HVVRHVERCE CKFIWCCYVR CRRCESMTDV HTCK
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

Gene References into Functions

A large number of Mef2c targets overlapped with genes down-regulated by Wnt16 and Mef2c itself was transcriptionally repressed by Wnt16 suggesting that Mef2c plays a role in Wnt16-mediated transcriptional regulation. PMID:29981832
that WNT16 plays a critical role for acquisition of both cortical and trabecular bone mass and strength PMID:28013361
WNT16 antagonises excessive canonical WNT activation and protects cartilage in osteoarthritis. PMID:27147711
Wnt16 Is Associated with Age-Related Bone Loss and Estrogen Withdrawal in Murine Bone PMID:26451596
Describe TGFbeta-Wnt16-Notch signaling conduit in the chondrocyte-like transformation of VSMCs and identify endogenous TGFbeta activity in MGP-null VSMCs as a critical mediator of chondrogenesis. PMID:25614285
Wnt5a abrogated the inhibitory effects of Wnt16 on Rankl-induced osteoclastogenesis PMID:26093292
These findings suggest that WNT16 acting via canonical WNT signaling regulates mechanical strain-induced periosteal bone formation and bone size. PMID:25521583
Osteoblast-derived WNT16 is a previously unreported key regulator of osteoclastogenesis and fracture susceptibility. PMID:25306233
Wnt16 is involved in intramembranous ossification and suppresses osteoblast differentiation through the Wnt/beta-catenin pathway. PMID:24037946
Study revealed new domains of expression for Wnt2, Wnt2b, Wnt5b, Wnt6, Wnt7b, Wnt9a, Wnt10a, Wnt10b, Wnt11 and Wnt16, in the limb. PMID:19185060