Recombinant Mouse Protein OS-9 (Os9)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Os9

Purity

>85% (SDS-PAGE)

Target Names

Os9

Uniprot NO.

Q8K2C7

Alternative Names

Os9; Protein OS-9

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

27-672

Target Protein Sequence

GVGS LNLEELSEMR YGIQILPLPV MGGQSQASDV VVVSSKYKQR YECRLPAGAI HFQREREEET PAYQGPGIPE LLSPMRDAPC LLKTKDWWTY EFCYGRHIQQ YHMEDSEIKG DVLYLGHYQS SFNWDDETAK ASKQHRLKRY HSQTYGNGSK CDLNGKPREA EVRFLCDEGA GISGDYIDRV DEPVSCSYVL TIRTSRLCPH PLLRPPASAA PQAILCHPAL QPDEYMAYLQ RQAESKQHEE KTTEEVQDTD RQVWSGSKAA GAPPKKEDVS PAKEEKESEL WKLQGPEEQA AAREEAQAGE QDLNHEAAAD PAPSPPNDFQ NNVQVKLIRS PADLIRLIEE LKAAEKGKPS VRREQPGDDT TEAPQREAEG TKAKGKDGEP PGLMEEEDGD DEEEEEEEEE DEEEQQLLGE FEKELEGMLL PSNRERLRSE VKAGMERELE NIIQETEKEL DPEGLRKESE REQAILALTS TLDKLIKRLQ ENQSPELVQK YKKRRVVPQK PPPSPHPTEE EPEHRVRVRV TKLRPGGPNR DLTVLEMNRE NPQLKQIEGL VTEVLEREGL TAEGKIEIKI VRPGAEGKEE DTRWLTDEDT RNLKEIFFNI LVQGAEEANK ERQRQSELES NYRRVWGSPG GEDTGDLDEF DF
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4.

Gene References into Functions

Data suggest renal cell lines exhibit an OS9-mediated ERAD (endoplasmic reticulum-associated degradation) pathway that degrades Nkcc2/Slc12a1 (solute carrier family 12 member 1) prior to glycosylation/processing. PMID:26721884
The depletion of OS-9 in 3T3-L1 adipocytes impaired cell function in terms of triacylglycerol storage, and slightly influenced cell differentiation. PMID:21523322
OS-9 regulates the secretory transport of TRPV4 and appears to protect TRPV4 subunits from the precocious ubiquitination and ER-associated degradation. PMID:17932042

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Subcellular Location

Endoplasmic reticulum lumen.

Protein Families

OS-9 family

Database Links

UNIGENE: Mm.295246

KEGG: mmu:216440

STRING: 10090.ENSMUSP00000128914

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