Recombinant Mouse Protein Mdm4 (Mdm4)

1. MDMX is an important regulator of p53 DNA binding, which complements the role of MDM2 in regulating p53 level. PMID:29581299
2. The p53-null mice with the highest level of Mdm4 tended to have multiple tumours. Mdm4 transgenic mice in various genetic backgrounds shows synergy in tumour development in vivo. Mdm4 may thus serve as a therapeutic target in cancers. PMID:27925213
3. Data show that the Mdm4-p73 axis cannot override the dominant role of p53 in development and tumorigenesis and that Mdm4 and p73 interaction during development and tumorigenesis suggests new insight into the role of p53 family members. PMID:26527653
4. MDM4/HIPK2/p53 cytoplasmic assembly uncovers coordinated repression of molecules with anti-apoptotic activity during early DNA damage response. PMID:25961923
5. MDMx degradation associated with neuronal death occurs via caspase activation in neurons, and that the progressive loss of MDMx protein represents a potential mechanism of Abeta-induced neuronal death during disease progression in AD PMID:26477779
6. Increased Mdm4-S mRNA levels might correlate with more aggressive cancers without encoding significant amounts of a potential oncoprotein. PMID:25088193
7. Decreased Mdm4 levels improves the survival of mice expressing wild-type p53, but not that of mice expressing a p53 hypomorph lacking the proline-rich domain. PMID:23474762
8. identify Mdm4 as one of these key mRNAs that senses the defects in the spliceosomal machinery and transduces the signal to activate the p53 response PMID:24013503
9. The work demonstrates that the ability of MDM4 to enhance p53 stability is actually a specific property of MDM4 accomplished upon DNA damage. PMID:22374672
10. Mdm4 was depleted by infecteing with wtHAdV or a mutant virus lacking the E1B-55K gene (dl 1520). PMID:22262167
11. hypoxia can activate p53 through inactivation of MDMX by the ATR-Chk1-MDMX-14-3-3gamma pathway. PMID:22556425
12. a new role for 14-3-3gamma in protecting p21 from MDMX-mediated proteasomal turnover, which may partially account for DNA damage-induced elevation of p21 levels independent of p53. PMID:21148311
13. Mdm4 is thus a bona fide oncogene in vivo and cooperates with p53 heterozygosity to drive tumorigenesis. PMID:20736370
14. Murine mdmx gene also contains a functional p53-responsive P2 promoter in intron 1, and mdmx-P2 transcripts are clearly induced in response to diverse p53-activating signals. PMID:20659896
15. The death of mdm4-null embryos is due to p53-initiated cell cycle arrest . PMID:14695178
16. p21 is a downstream modifier of Mdm4, and provides genetic evidence that Mdm4 can function to regulate cell growth both positively and negatively. PMID:14712235
17. Mdmx overexpression allows primary mouse embryonic fibroblast immortalization and leads to neoplastic transformation in combination with HRas(V12). PMID:15199139
18. virtually all these data pointed toward a critical role for Mdmx in the regulation of the p53-Mdm2 network [review] PMID:15865931
19. Mdm4 cannot compensate for the loss of Mdm2 in heart development. PMID:16354690
20. MDM4 is alternatively spliced following UV irradiation. Alternate forms of MDM4 place selective pressure on the cells to acquire additional alterations in the p53 pathway. PMID:17018606
21. Mdm4 only contributes to p53 regulation at a specific phase of the differentiation program PMID:17105817
22. G alpha(12/13) regulate basal p53 levels via mdm4, which constitutes a cell signaling pathway distinct from p53 phosphorylations elicited by genotoxic stress. PMID:17510313
23. Activity of p53 was inhibited by Mdm4 even in the fully differentiated cardiomyocyte. Elevated apoptosis mediated by the p53 pathway in cardiomyocytes may be a mechanism for dilated cardiomyopathy. PMID:17533180
24. These data show that MDMX is an antiapoptotic factor in neurons, whose degradation is induced by various stresses and allows activation of p53 and E2F-1 during neuronal apoptosis. PMID:17823617
25. These results indicate that MdmX has a p53-independent role in suppressing oncogenic cell transformation, proliferation, and tumorigenesis by promoting centrosome clustering and bipolar mitosis. PMID:18039860
26. These data define a new localization and function of MDM4 that, by acting as a docking site for p53Ser46(P) to BCL2, facilitates the p53-mediated intrinsic-apoptotic pathway. PMID:19521340
27. Mdmx downregulation is crucial for effective p53-mediated radiation responses and tumor suppression in vivo in a mouse model of B cell lymphoma. PMID:19573810

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UNIGENE: Mm.426531

KEGG: mmu:17248

STRING: 10090.ENSMUSP00000070411