Recombinant Mouse Protein BTG1 (Btg1)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Btg1

Uniprot NO.

P62325

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-171

Target Protein Sequence

MHPFYTRAAT MIGEIAAAVS FISKFLRTKG LTSERQLQTF SQSLQELLAE HYKHHWFPEK PCKGSGYRCI RINHKMDPLI GQAAQRIGLS SQELFRLLPS ELTLWVDPYE VSYRIGEDGS ICVLYEASPA GGSTQNSTNV QMVDSRISCK EELLLGRTSP SKNYNMMTVS G
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Anti-proliferative protein.

Gene References into Functions

Subventricular zone stem cells are endowed with a hidden supply of self-renewal capacity, coupled to cell cycle acceleration and emerging after ablation of the quiescence-maintaining Btg1 gene and following exercise. PMID:28247022
Tumor suppressors BTG1 and BTG2 regulate early mouse B-cell development. PMID:27036158
our results identify BTG1 as a tumor suppressor in leukemia that, when deleted, strongly enhances the risk of relapse in IKZF1-deleted B-cell precursor acute lymphoblastic leukemia, and augments the glucocorticoid resistance phenotype mediated by the loss of IKZF1 function. PMID:27979924
the findings provide evidence for a role of Btg1 regulating the initial differentiation of cartilage and tendons. PMID:26662056
BTG1 overexpression or knockdown improved or impaired insulin signaling respectively. PMID:26396236
Btg1 regulates the proliferation of cerebellar granule precursors selectively through cyclin D1. PMID:26524254
these data show that both Btg1 and Btg2 are required for normal vertebral patterning of the axial skeleton, but each gene contributes differently in specifying the identity along the anterior-posterior axis of the skeleton. PMID:26218146
Btg1 gain- and loss-of-function experiments were consistent with the pattern of expression of this gene in the developing digits. We detected a negative influence of BTG1 in the progress of cartilage maturation and a positive influence in the formation of fibrogenic tissue. PMID:26662056
Antiproliferative BTG1 may participate in the activation-induced cell death of microglia by lowering the threshold for apoptosis. PMID:14634089