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Recombinant Mouse Prostaglandin E synthase 2 (Ptges2), partial

Recombinant Mouse Prostaglandin E synthase 2 (Ptges2), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Ptges2

Purity

>85% (SDS-PAGE)

Target Names

Ptges2

Uniprot NO.

Q8BWM0

Alternative Names

Ptges2; Gbf1; Pges2; Prostaglandin E synthase 2; EC 5.3.99.3; GATE-binding factor 1; GBF-1; Microsomal prostaglandin E synthase 2; mPGES-2) [Cleaved into: Prostaglandin E synthase 2 truncated form]

Species

Mus musculus (Mouse)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro). The biological function and the GSH-dependent property of PTGES2 is still under debate. In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA). May also have transactivation activity toward IFN-gamma (IFNG), possibly via an interaction with CEBPB; however, the relevance of transcription activation activity remains unclear.

Gene References into Functions

mPGES-2 deletion enhanced streptozotocin (STZ)-induced liver toxicity possibly via GLUT2-mediated STZ uptake, independently of diabetes mellitus in mice. PMID:25076362
increased expression of miR-146a in bone marrow-derived mesenchymal stem cells correlated with inhibition of prostaglandin E2 synthase-2 and inhibition of prostaglandin E2 release. PMID:23589616
Transactivators GBF1 and CCAAT/enhancer-binding protein-beta physically interact to induce interferon-gamma-regulated transcription; a 37-aa long peptide derived from the GBF1 protein can associate with C/EBP-beta in an IFN-inducible manner. PMID:15879117
In the urogenital system, membrane-associated PGES-2 was highly expressed in the renal cortex, followed by the renal medulla and ovary, with lower levels in the ureter, bladder and uterus. PMID:17064959
Study suggests that in hypertensive mice, there are (a) significant microanatomic variations in the pulmonary, renal, and cardiac distribution and cellular localization of mPGES-2 and no differences in expression between genders. PMID:17641732
Analysis of the mPGES-2 deficient mouse lines does not substantiate the contention that mPGES-2 is a PGE(2) synthase. PMID:19010439
This article reviews the involvement of the PGE(2), Wnt, and BMP pathways in the development of gastric cancer. PMID:19622104
PGE(2) protects the pulmonary vasculature from remodeling during allergen-induced pulmonary inflammation PMID:20028661