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Recombinant Mouse Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (Plod2)

Recombinant Mouse Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (Plod2)

Mammalian cell

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Plod2

Purity

>85% (SDS-PAGE)

Target Names

Plod2

Uniprot NO.

Q9R0B9

Alternative Names

Plod2; Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2; EC 1.14.11.4; Lysyl hydroxylase 2; LH2

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

26-737

Target Protein Sequence

VAEET PGRIPADKLL VITVATKEND GFHRFMNSAK YFNYTVKVLG QGQEWRGGDG MNSIGGGQKV RLLKEAMEHY ASQEDLVILF TECFDVVFAG GPEEVLKKFQ KTNHKIVFAA DGLLWPDKRL ADKYPVVHIG KRYLNSGGFI GYAPYISRLV QQWNLQDNDD DQLFYTKVYI DPLKREAFNI TLDHKCKIFQ ALNGATDEVV LKFENGKSRV KNTFYETLPV AINGNGPTKI LLNYFGNYVP NSWTQENGCA LCDVDTIDLS TVDVPPKVTL GVFIEQPTPF LPRFLNLLLT LDYPKEALQL FIHNKEVYHE KDIKVFVDKA KHDISSIKIV GPEENLSQAE ARNMGMDFCR QDEKCDYYFS VDADVVLTNP RTLKFLIEQN RKIIAPLVTR HGKLWSNFWG ALSPDGYYAR SEDYVDIVQG NRVGIWNVPY MANVYLIQGK TLRSEMNERN YFVRDKLDPD MALCRNARDM GVFMYISNRH EFGRLISTAN YNTSHLNNDF WQIFENPVDW KEKYINRDYS KIFTENIVEQ PCPDVFWFPI FSERACDELV EEMEHYGKWS GGKHHDSRIS GGYENVPTDD IHMKQIGLEN VWLHFIREFI APVTLKVFAG YYTKGFALLN FVVKYSPERQ RSLRPHHDAS TFTINIALNN VGEDFQGGGC KFLRYNCSIE SPRKGWSFMH PGRLTHLHEG LPVKNGTRYI AVSFIDP
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.

Gene References into Functions

FKBP65 regulates LH2-mediated collagen cross-linking. PMID:28378777
The finding that LH2 modifies collagen in the extracellular space challenges the current view that LH2 functions solely on the endoplasmic reticulum and could also have important implications for cancer biology. PMID:27803159
Authors propose that lysyl hydroxylase 2, and the subsequent increase in pyridinoline cross-links, is responsible for the persistent fibrosis in experimental osteoarthritis. PMID:23069856
Lysyl hydroxylase-2b directs collagen cross-linking pathways through its action on telopeptidyl lysine residues. PMID:15231023
LH2b catalyzes post-translational modification of collagen in collagen matrix formation and mineralization in bone. PMID:15619673
analysis of the specific regulation for the expression of LH isoforms as well as for alternative splicing of LH2 during embryogenesis and in different tissues PMID:16996725