Recombinant Mouse Pro-cathepsin H (Ctsh)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Ctsh

Uniprot NO.

P49935

Alternative Names

Ctsh; Pro-cathepsin H; Cathepsin B3; Cathepsin BA) [Cleaved into: Cathepsin H mini chain; Cathepsin H; EC 3.4.22.16); Cathepsin H heavy chain; Cathepsin H light chain]

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

96-103

Target Protein Sequence

EPQNC SAT
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Important for the overall degradation of proteins in lysosomes.

Gene References into Functions

CatH deficiency impaired toll-like receptor 3-mediated activation of interferon regulatory factor 3 and consequent secretion of IFN-beta PMID:29470604
The data provide strong evidence that CTSH is an important regulator of beta-cell function during progression of T1D PMID:24982147
Cathepsin H knockout mice show reduced brain levels of (Met)enkephalin and galanin. PMID:22582844
cathepsin H is involved in the SP-B production. PMID:22022579
CTSH overexpression in a subset hepatoma may be thyroid hormone receptor dependent and suggests that this overexpression has an important role in hepatoma progression. PMID:21217776
In two mouse models of pancreatic islet cancer, deletion of CtsH reduced tumor progression; mechanisms involved impaired angiogenic switching from premalignant state, poor vascularization of tumors, and increased apoptosis. PMID:20731543
In proteolipid protein transgenic mice cathepsin H is upregulated primarily in microglia/macrophages of white matter. PMID:17086443
Presence of cathepsin H and (bone morphogenetic protein 4)BMP4 in lung or other developing organs suggest that cathepsin H regulates BMP4 proteolysis in morphogenesis. PMID:17500053