Recombinant Mouse Presenilin-2 (Psen2), partial

1. These observations illustrate a novel PS2-dependent means of modulating LPS-mediated immune responses and identify a functional distinction between PS1 and PS2 in innate immunity. PMID:26081153
2. Although hyperactivity and hypersynchronicity were respectively detected in mice expressing the PS2-N141I or the APP Swedish mutant alone, the increase in cross-frequency coupling specifically characterized the 6-month-old PS2APP mice, just before the surge of the cognitive decline PMID:27889678
3. Presenilin 2 (PS2), mutations in which underlie familial Alzheimer's disease (FAD), promotes endoplasmic reticulum-mitochondria coupling only in the presence of mitofusin 2 (Mfn2). PMID:27239030
4. Results suggest that mutation of PS2 can lead to NF-kappaB mediate amyloidogensis, and this effect can be amplified by the absence of estrogen. PMID:26593275
5. The loss of PS2 could have a critical role in lung tumor development through the upregulation of iPLA2 activity by reducing gamma-secretase. PMID:24858037
6. One mechanism by which PS2 works to reign in proinflammatory microglial behavior and PS2 dysfunction or deficiency could result in unchecked proinflammatory activation. contributing to neurodegeneration. PMID:23952003
7. Interactome analyses of mature gamma-secretase complexes reveal distinct molecular environments of presenilin (PS) paralogs and preferential binding of signal peptide peptidase to PS2. PMID:23589300
8. Distribution and expression profile of Psen2 differs from Psen1 in the cerebral cortex during development. PMID:22796216
9. PS2 mutation significantly accelerates the onset of cognitive impairment in associative trace eyeblink memory. PMID:23370287
10. Presenilin 2 has the ability to regulate nectin-1 processing. PMID:21910732
11. Presenilin-2 dampens intracellular Ca2+ stores by increasing Ca2+ leakage and reducing Ca2+ uptake PMID:19382908
12. Study supports the hypothesis that Pen-2 is more than a structural component of the gamma-secretase complex and may contribute to the catalytic mechanism of the enzyme. PMID:21296884
13. PS2 is the predominant gamma-secretase in microglia and modulates release of proinflammatory cytokines PMID:21206757
14. Endogenous wild-type presenilin 2 is necessary for proper protein degradation through the autophagosome-lysosome system by functioning at the lysosomal level. PMID:21414900
15. 4-O-Methylhonokiol attenuates memory impairment in presenilin 2 mutant mice . PMID:20974250
16. partial, but highly significant, loss of mGlur2 receptors in amyloid-affected discrete brain regions of Alzheimer cases and PS2APP mice PMID:20875805
17. this study shows that the contribution of PS2 on gamma-secretase activity is of less importance, explaining the mild phenotype of PS2-deficient mice. PMID:21146496
18. inhibits protein synthesis PMID:11817902
19. PS2/gamma-secretase contains PEN-2 and requires it for presenilin expression PMID:12198112
20. Results establish a critical role of presenilin 2 in myelopoiesis; partial loss of PS2 in mice leads to age-dependent myeloproliferative disease, mediated through its gamma-secretase activity. PMID:15122901
21. Expression of mutant presenilin 2(M239V-PS2) caused neuronal cytotoxicity which could be inhibited by the combination of two clinically usable inhibitors of superoxide-generating enzymes, apocynin and oxypurinol PMID:15264228
22. The metabolic profile, however, showed clear indicators of hypometabolism with age in the PS2APP mice: both N-acetyl-aspartate and glutamate were significantly reduced in the older animals. PMID:15649694
23. presenilin 2 may be implicated in neuronal cell death by altering the antiapoptotic activity of the transcription factors PMID:15858415
24. PS2 plays an important role in cardiac excitation-contraction coupling by interacting with RyR2 PMID:16204356
25. the promoter of the mouse Presenilin-2 gene is bound and activated by CLOCK and BMAL1, transcription factors of the mammalian circadian clock PMID:16887746
26. Findings indicate that PS2 is involved in the abnormalities of the lipid profile, which could cause or result in Alzheimer's disease. PMID:17121184
27. C-terminal fragment of presenillin 2 is released by shedding into the extracellular compartment as a soluble form. This release is 4.07-fold increased during apoptosis. PMID:17292944
28. PS2 is necessary for the proteolytic activity of gamma-secretase. PMID:17556541
29. Thus these results demonstrate up-regulation of PS2 protein expression by sex steroids, which in turn may influence PS2 associated brain functions. PMID:17728018
30. Data demonstrate facilitation of ryanodine receptor gating by presenilin-2 NTF1-87. PMID:18440065
31. PS2 mutation causes reduction of anxiety PMID:18803281
32. PS2beta may inhibit gamma-secretase activity by affecting the gamma-secretase complex assembly PMID:19376115
33. Egr-1 over-expression and down-regulation, as well as in-vivo examination of Egr-1 and Psen2 expression during fear conditioning, showed that Egr-1 does not regulate the Psen2 promoter. PMID:19573580

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UNIGENE: Mm.330850

KEGG: mmu:19165

STRING: 10090.ENSMUSP00000010753