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Recombinant Mouse Poliovirus receptor-related protein 2 (Pvrl2), partial

Recombinant Mouse Poliovirus receptor-related protein 2 (Pvrl2), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Nectin2

Uniprot NO.

P32507

Alternative Names

Nectin2; Mph; Pvr; Pvrl2; Pvs; Nectin-2; Herpes virus entry mediator B; Herpesvirus entry mediator B; HveB; Murine herpes virus entry protein B; mHveB; Nectin cell adhesion molecule 2; Poliovirus receptor homolog; Poliovirus receptor-related protein 2; CD antigen CD112

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

32-351

Target Protein Sequence

QDVRVRVLP EVRGRLGGTV ELPCHLLPPT TERVSQVTWQ RLDGTVVAAF HPSFGVDFPN SQFSKDRLSF VRARPETNAD LRDATLAFRG LRVEDEGNYT CEFATFPNGT RRGVTWLRVI AQPENHAEAQ EVTIGPQSVA VARCVSTGGR PPARITWISS LGGEAKDTQE PGIQAGTVTI ISRYSLVPVG RADGVKVTCR VEHESFEEPI LLPVTLSVRY PPEVSISGYD DNWYLGRSEA ILTCDVRSNP EPTDYDWSTT SGVFPASAVA QGSQLLVHSV DRMVNTTFIC TATNAVGTGR AEQVILVRES PSTAGAGATG G
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. Probable cell adhesion protein.

Gene References into Functions

PVRL2 is a plasma cholesterol-responsive gene acting at endothelial sites of vascular inflammation to regulate transendothelial migration of leukocytes. PMID:28062492
Results suggest that modulation of the expression of receptors and CD112 compensates for CD155 deficiency in immune surveillance against methylcholanthrene-induced tumors. PMID:25384044
We showed that cadherin and nectin in the junctions of A431 cells and human keratinocytes are located in separate clusters. PMID:23639974
nectin-afadin system plays essential roles in coupling cell-cell adhesion and the cortical actin scaffold in spermatids at Sertoli-spermatid junctions and in subsequent sperm morphogenesis PMID:12121624
Our functional analyses indicate that the infertility phenotype of nectin-2-deficient male mice is caused by a combination of reduced migration to the oviduct, spermatozoa-zona binding, and sperm-oocyte fusion PMID:12801998
Nectin-2 expression in Sertoli cells is believed via cross-talking between CREB, c-Jun, and Sp1 family protein. PMID:16250013
Inactivated nectin-2 and nectin-3 disrupted the nectin-afadin-actin system, and finally the actin filaments disappeared. As a result, the specialization lost the holding function and detachment of spermatids was observed. PMID:18097512
expressed in early epithelial structures of the nephron generated from metanephric mesenchyme PMID:19116242
Nectin-2 is required to maintain structure and function of the intercalated disc and protects the heart from pressure-overload-induced cardiac dysfunction. PMID:19667252