Recombinant Mouse Platelet receptor Gi24, partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Vsir

Uniprot NO.

Q9D659

Alternative Names

Vsir; Dies1; PD-1H; VISTA; V-type immunoglobulin domain-containing suppressor of T-cell activation; Platelet receptor Gi24; V-set domain-containing immunoregulatory receptor; V-set immunoregulatory receptor

Species

Mus musculus (Mouse)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Immunoregulatory receptor which inhibits the T-cell response. May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling. May stimulate MMP14-mediated MMP2 activation.

Gene References into Functions

The study demonstrates a novel role of v-domain immunoglobulin suppressor of T cell activation (VISTA) in regulating this inflammatory axis. In the IMQ-induced psoriasis model, VISTA deficiency augmented the inflammatory responses of dendritic cells, gammadelta T cells, and Th17 cells, resulting in exacerbated psoriasiform dermatitis. PMID:28469254
VISTA expression supports immune-complex inflammation in collagen antibody-induced arthritis and VISTA is expressed in human synovium PMID:29216931
Dies1 expression loss is a recurrent event in gastric cancer, caused by promoter methylation. PMID:27721458
Blockade with a combination of iNOS/NO and VISTA caused additive or synergistic abrogation of MDSC-mediated suppression of B-cell responsiveness. PMID:26157131
The ectopic expression of miR-125b blocks ESC differentiation at the epiblast stage, and this arrest is rescued by restoring the expression of Dies1. PMID:23807506
study demonstrates the nonredundant role of VISTA that is distinct from the PD-1/PD-L1 pathway in controlling T-cell activation PMID:25964334
PD-1H is a coinhibitory receptor on alloreactive T cells and functions in the regulation of T cell tolerance. PMID:25917101
VISTA is a negative checkpoint regulator whose loss of function lowers the threshold for T-cell activation. PMID:25267631
Coinhibitory receptor PD-1H preferentially suppresses CD4 T cell-mediated immunity PMID:24743150
data identify Dies1 as a new differentiation-dependent adipocyte plasma membrane protein whose expression is required for effective adipogenesis PMID:23799023
A regulatory loop involving Dies1 and miR-125a controls BMP4 signaling in mouse embryonic stem cells. PMID:22751012
Dies1 mediates BMP4 signalling that controls the transcription of miR-125a gene that, in turn, regulates Dies1 expression. PMID:22751012
Results demonstrate that Dies1 is required for BMP4/Smad1 signaling cascade. PMID:20042595
Dies1 is a necessary factor of BMP4 signaling and its suppression sustains mESC self-renewal. PMID:20042595

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Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Tissue Specificity

Expressed in spleen, thymus, bone marrow, lymph node, and in T-cells within the lamina propria of the small intestine. Detected on CD4+ and CD8+ T-cells, bone marrow-derived dendritic cells (BMDCs), peritoneal macrophages, neutrophils, and natural killer

Database Links

UNIGENE: Mm.273584

KEGG: mmu:74048

STRING: 10090.ENSMUSP00000020301

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