Recombinant Mouse Phosphoinositide 3-kinase regulatory subunit 4 (Pik3r4), partial

Product Details

Abbreviation
Pik3r4
Purity
>85% (SDS-PAGE)
Target Names
Pik3r4
Uniprot NO.
Alternative Names
Pik3r4; Vps15; Phosphoinositide 3-kinase regulatory subunit 4; PI3-kinase regulatory subunit 4; EC 2.7.11.1
Species
Mus musculus (Mouse)
Source
Yeast
Expression Region
2-1358
Target Protein Sequence
GNQLAGIAP SQILSVESYF SDIHDFEYDK SLGSTRFFKV ARAKHREGLV VVKVFAIQDP TLPLTSYKQE LEELKIRLHS AQNCLPFQKA AEKASEKAAM LFRQYVRDNL YDRISTRPFL NNIEKRWIAF QILTAVDQAH KSGVRHGDIK TENVMVTSWN WVLLTDFASF KPTYLPEDNP ADFNYFFDTS RRRTCYIAPE RFVDGGMFAT ELEYMRDPST PLVDLNSNQR ARGELKRAMD IFSAGCVIAE LFTEGVPLFD LSQLLAYRNG HFFPEQVLNK IEDRSIRDLV TQMINREPEK RLEAEDYLKQ QRGNAFPEIF YTFLQPYMAQ FAKETFLSAD ERILVIRKDL GNIIHNLCGH DLPEKAEGES RASGLVVLVS VITSCLQTLK SCDSKLAALE LILHLAPRLS VEILLDRITP YLLHFSNDSV PRVRAEALRT LTKVLALVQE VPRNDVNIYP EYILPGIAHL AQDDATIVRL AYAENIALLA ETALRFLELV QLKTLNMENE PDNEEVDEAT RPNGDYDTEL QALHEMVQQK VVTLLSDPEN IVKQTLMESG ITRLCVFFGR QKANDVLLSH MITFLNDKND WHLRGAFFDS IVGVAAYVGW QSSSILKPLL QQGLSDAEEF VIVKALNALT CMCQLGLLQK PHVYEFASDI APFLCHPNLW IRYGAVGFIT VVAHQISTAD VYCKLMPYLD PYITQPVIQI ERKLVLLSVL KEPVSRSIFD YALRSKDIAS LFRHLHMRQK KRNGSLLDCP PPEDPTIAQL LKKLLSQGMT EEEEDKLLAL KDFMMKSNRA KANAVDQSHL HDSSQKGVID LAALGITGRQ VDLVKTKQEP DEKRARKHVK QDSNVNEEWK SMFGSLEPPN IPQALPKTSD HEVVQPGKPP RSESSAGICV PLSTSPQVSE AAHIPSKKPV IPVVSSTVLP STYQIRITTC KTELQQLIQQ KREQCNAERI AKQMMENAEW ESKPPPPGWR PKGLLVAHLH EHKSAVNRIR VSDEHLLFAT CSNDGTVKIW NSQKMEGKTT TTRSILTYSR IGGRVKTLTF CQGSHYLAIA SDNGAVQLLG IEASKLPKSP KIHPLQSRIL DQKEDGCVVD MHHFNSGAQS VLAYATVNGS LVGWDLRSSS NAWTLKHDLK SGLITSFAVD IHQCWLCIGT SSGAMACWDM RFQLPISSHC HPSRARIRRL SMHPLYQSWV IAAVQGNNEV SMWDMETGDR RLTLWASSAP PLSELQPSPH SVHGIYCSPA DGNPILLTAG SDMKIRFWDL VSPERSYVVA GSTGSPSVSY YKKIIEGTEV VQEIQNKQKV GPSDDTPRRG PESLPVGHHD IITDIATFQT TQGFIVTASR DGIVKVWK
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
Protein Length
Partial
Tag Info
N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Storage Condition
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)
Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2.
Gene References into Functions
  1. Vps15-deficient mouse tissues are competent for LC3-positive autophagosome formation and maintain mTOR activation. PMID:23630012

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Subcellular Location
Late endosome. Cytoplasmic vesicle, autophagosome. Membrane; Lipid-anchor.
Protein Families
Protein kinase superfamily, Ser/Thr protein kinase family
Database Links
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