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Recombinant Mouse Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein (Prex2), partial

Recombinant Mouse Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein (Prex2), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Prex2

Purity

>85% (SDS-PAGE)

Target Names

Prex2

Uniprot NO.

Q3LAC4

Alternative Names

Prex2; Depdc2; Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein; P-Rex2; PtdIns(3,4,5)-dependent Rac exchanger 2; DEP domain-containing protein 2

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-1598

Target Protein Sequence

MSDESAREVD KQLRLRVCVL SELQKTERDY VGTLEFLVSA FLHRMNQCAA AKVDKNVTEE TVKMLFSNIE EILIVHKEFL KVVEECLYPE PSAQQEVGAC FLHFKDKFRI YDEYCSNHEK AQKLLLELNK IRTIRTFLLN CMLLGGRKNT DVPLEGYLVT PIQRICKYPL LLKELLKRTP RRHSDYTAVM EALQAMKAVC SNINEAKRQM EKLEVLEEWQ AHIEGWEGSN ITDTCTEMLM CGVLMKISSG NIQERVFFLF DNLLVYCKRK HRRLKNSKAS TDGYRYVFRG RINTEVMEVE NVDDGTADFH SSGHIVVNGW KIHNTAKNKW FVCMAKSPEE KHEWFEAILK ERERRKGLKL GMEQDTWVMI SEQGEKLYKM MCKQGNLIKD RKRKLTTFPK CFLGSEFVSW LLEIGEIHRP EEGVHLGQAL LENGIIHHVT DKHQFKPEQM LYRFRYDDGT FYPRSEMQDV ISKGVRLYCR LHSLFTPVVR DKDYHLRTYK SVVMANKLID WLIAQGDCRT REEAMIFAVG LCDNGFMHHV LEKSEFKDEP LLFRFFADEE MEGSNMKHRL MKHDLKVVEN VIAKSLLIKS NEGSYGFGLE DKNKVPIIKL VEKGSNAEMA GMEVGKKIFA INGDLVFLRP FPEVDCFLKS CLNSRKPLRV LVSTKPRETV KIPDSADGLG FQIRGFGPSV VHAVGRGTVA AAAGLHPGQC IIKVNGINVS KETHASVIAH VTACRKYKRP MKQDSIQWVY DSLESAQEDI QKSHSKPPGD GAGDAFECKV EDVIDKFNTM AIIDGKKEHV SLTVDNVHLE YGVVYEYDST AGTKCNVVEK MVEPKGFFSL TAKILEALAK SDEHFVQNCT SLNSLNEVIA TDLQSKFTSM CSERIEHVCH RISSYGRFSR VLKNRAWPTF KQAKPKISPL HSSDFCPTNC HVNVMEVSYP KTSTSLGSAF GVQLDSRKHN SHDKENKSVE PGKLSPMVYI QHTITTMAAP SGLSLGHKDG HGLQYLLKEE DLETQDIYHK LLGKLQTALK EVEMSVCQID DLLSSITYSP KLERKTTECV TPMDSDNEKG ERNSKRVCFN VAGDEQEDSG HDTVSNRDSY SDCNSNRNSI ASFTSICSSQ CSSYFHSDEM DSGDELPISV RISHDKQDKI HTCLEQLFSQ IDSIINLLKG QAVIRAFEQT KYLTPGRGLQ EFQQEMEAKL SCPRRLRLHL KQDPWNLPSS IQALAQSIRK HAEEVKCRIL LALLEYSDSE TQLRRDMVFC QSLVATVCAF SEQLMAALNQ MFDNSKENEM ETCEASRRWL DQIANAGVLF HFQSLLSPNL KDEQAMLEDT LVALFDLEKV SFFFKPSEED PLVANVPLTY QVEGSRQALK VYFYMDSYHF EQLPQRLKNG GGFKIHPVLF SQALESMEGY CYRDNISVEE FQAQINTASL EKVKQYNQKL RAFYLDKSNS PPNTTSKAAY IDKLMKPLNA LDELYRLITS FIRSKRIAAC VNTPCSASGV GLLSVSSELC DRLGACHIIM CSSGVHRCTL SVTLEQTITL ARSHGLPPRY IMQAMDVMRK QGARVQNTAK NLGVRDRTPQ SAPRLYKLCE PPPPVGEE
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase.

Gene References into Functions

complex signaling mechanisms that involve PREX2, PI3K/AKT/PTEN and downstream epigenetic machinery to deregulate expression of key cell cycle regulators PMID:27111337
P-REX2 PH-domain-mediated inhibition of PTEN has a role in regulating insulin sensitivity and glucose homeostasis PMID:24367090
This study demonistrated that the P-Rex2, a GEF that specifically activates Rac small GTPases, is expressed in a cell- and synapse-specific manner in the retina. PMID:23844743
PI3K/P-Rex/Rac pathway is required for late phase long-term potentiation in the mouse cerebellum PMID:20694145
P-Rex1 and P-Rex2 are important regulators of Purkinje cell morphology and cerebellar function PMID:18334636