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Recombinant Mouse Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (Prex1), partial

Recombinant Mouse Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (Prex1), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Prex1

Purity

>85% (SDS-PAGE)

Target Names

Prex1

Uniprot NO.

Q69ZK0

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-1650

Target Protein Sequence

MEAPGSGGGD GGGDPGGDGA HPDARGPVSG PCAAARDSER QLRLRLCVLN EILGTERDYV GTLRFLQSAF LQRIRQNVAD SVEKGLTEEN VKVLFSNIED ILEVHKDFLA ALEYCLHPEP QSQHELGNVF LKFKDKFCVY EEYCSNHEKA LRLLVELNKV PAVRAFLLSC MLLGGRKTTD IPLEGYLLSP IQRICKYPLL LKELAKRTPG KHPDHTAVQS ALQAMKTVCS NINETKRQME KLEALEQLQS HIEGWEGSNL TDICTELLLQ GNLLKISAGN IQERAFFLFD NLLVYCKRKS RVTGSKKSTK RTKSINGSLY IFRGRINTEV MEVENVEDGT ADYHSNGYTV TNGWKIHNTA KNKWFVCMAK TAEEKQKWLD ALIREREQRE SLKLGMERDA YVMIAEKGEK LYHMMMSKKV NLIKDRRRKL STVPKCFLGN EFVAWLLEIG EISKTEEGVN LGQALLENGI IHHVSDKHQF KNEQVMYRFR YDDGTYKARS ELEDIMSKGV RLYCRLHSLY APVIKDRDYH LKTYKSVVPG SKLVDWLLAQ GDCQTREEAV ALGVGLCNNG FMHHVLEKSE FKDESQYFRF HADEEMEGTS SKNKQLRNDF KLVENILAKR LLIPPQEDDY GFDLEEKNKA VVVKSVQRGS LAEMAGLQAG RKIYSINEDL VFLRPFSEVE TILNQFFCSR RPLRLLVATK AKETIKVPDH PEALSFQIRG TAPPCVFAVG RGSEAVAAGL CAGQCILKVN GTSVANDGAL EVLEHFQAFR NHREEALGLY QWVYHSHEDA QLARASQGAP DEDPQEDDQP DSALPLLSLG PQLSLHEDSA VVSLTLDNVH LEHGVVYEYM STAGAKCHVL EKIVEPRGCF RLAAKILEAF AVDDSIFVQN CGRLMAMSSA IVTMSHYEFH NICDTKLESI GQRIACYQEF AAQLKSRVSP PFKQASLEPH PLCGLDFCPT NCHVNLMEVS YPKTTPSVGR SFSIRFGRKP SLIGLDPEQG LNPMAYTQHC ITTMAAPSWK CSPAVDEDSQ GQGLNDSSYG SASGAPSQQD RGLSFLLKQE DREIQDAYLQ LFTKLDVALK EMKQYVTQIN RLLSTITEPT SAAPAPCDPS LVEETSSSPP VSEESEVDRT DHSGIKKVCF KVSEDEQEDS GHDTMSYRDS YSECNSNRDS VLSYTSVRSN SSYLGSDEMG SGDELPCDMR IPSDKQDKLH GCLEHLFNQV DSIHALLKGP VMSRAFEETR HFPMKHSWQE FKQKEECTVR GRNLIQISIQ EDPWNLPSSI RTLVDNIQQY VEDGKNQLLL ALLKCTDTEL QLRRDAVFCQ ALVAAVCTFS EQLLAALDYR YNNNGEYEES SRDASRKWLE QVAATGVLLH WQSLLAPASV KEERTMLEDI WVTLSELDNV TFSFKQLDEN SVANTNVFYH IEGSRQALKV VFYLDGFHFS RLPSRLEGGA SLRLHTVLFT KALESVEGPP PPGNQAAEEL QQEINAQSLE KVQQYYRKLR AFYLERSNLP TDAGATAVKI DQLIRPINAL DELYRLMKTF VHPKAGAAGS LGAGLIPVSS ELCYRLGACQ ITMCGTGMQR STLSVSLEQA AILARSHGLL PKCVMQATDI MRKQGPRVEI LAKNLRIKDP MPQGAPRLYQ LCQPPVDGDL
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.

Gene References into Functions

These findings identify P-Rex1 as a novel player of pulmonary fibrosis. PMID:27173636
A novel mechanism of P-Rex1 regulation through the GPCR-adaptor protein Norbin. PMID:26792863
Tiam1 and P-Rex1 promote Rac1 anti- and pro-migratory signalling cascades. PMID:26887924
findings suggest a vital role of P-Rex1 signaling in CA1 LTD that is critical for social behavior and cognitive function and offer new insight into the etiology of ASDs PMID:26621702
regulates GPCR-driven Rac signalling and actin polarity in neutrophils PMID:24659802
Platelet P-Rex and Vav family Rac-GEFs play important proinflammatory roles in leukocyte recruitment. PMID:25538043
We have elucidated a proliferative role of P-Rex1 when Rac1 is deleted in melanoblasts. PMID:25075639
P-Rex1 may serve as a biomarker to predict response to single-agent PI3K inhibitors within a subset of breast cancers. PMID:24327733
In vivo, in an ischemia-reperfusion-induced model of acute kidney injury, abolished selectin-mediated integrin activation contributed to decreased neutrophil recruitment and reduced kidney damage in P-Rex1-deficient mice. PMID:23343834
P-rex1 expressed in endothelial cells is a critical mediator of vascular barrier disruption by an upstream pathway. PMID:22965143
Data conclude that P-Rex1 has an important role in melanoblast migration and cancer progression to metastasis in mice and humans. PMID:22109529
Demonstrate presence of P-Rex1 in platelets as well as its role in platelet secretion and aggregation induced by low-dose agonists for g-protein coupled receptors and by collagen. PMID:22207728
Studies identify a novel RacGEF in adipocytes as P-Rex1 that, at physiological insulin concentrations, functions as an insulin-dependent regulator of the actin cytoskeleton that contributes to GLUT4 trafficking to the plasma membrane. PMID:22002247
Either P-Rex1 or Vav1 alone can produce sufficient active Rac for G protein-coupled receptor-dependent cell responses but under normal circumstances both contribute, presumably to ensure robust cell responses of primary neutrophils. PMID:21178006
P-Rex1 is an important regulator of neutrophil function by mediating a subset of Rac-dependent neutrophil responses. PMID:16243035
P-Rex1 is a primary Rac2 guanine nucleotide exchange factor in mouse neutrophils. PMID:16243036
P-Rex1 is one of the major GEFs in macrophage regulating Rac1 activation and chemotaxis. PMID:18502673