Recombinant Mouse Paired box protein Pax-8 (Pax8)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Pax8

Uniprot NO.

Q00288

Alternative Names

Pax8; Pax-8; Paired box protein Pax-8

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-457

Target Protein Sequence

MPHNSIRSGH GGLNQLGGAF VNGRPLPEVV RQRIVDLAHQ GVRPCDISRQ LRVSHGCVSK ILGRYYETGS IRPGVIGGSK PKVATPKVVE KIGDYKRQNP TMFAWEIRDR LLAEGVCDND TVPSVSSINR IIRTKVQQPF NLPMDSCVAT KSLSPGHTLI PSSAVTPPES PQSDSLGSTY SINGLLGIAQ PGNDNKRKMD DSDQDSCRLS IDSQSSSSGP RKHLRTDTFS QHHLEALECP FERQHYPEAY ASPSHTKGEQ GLYPLPLLNS ALDDGKATLT SSNTPLGRNL STHQTYPVVA DPHSPFAIKQ ETPELSSSSS TPSSLSSSAF LDLQQVGSGG PAGASVPPFN AFPHAASVYG QFTGQALLSG REMVGPTLPG YPPHIPTSGQ GSYASSAIAG MVAGSEYSGN AYSHTPYSSY SEAWRFPNSS LLSSPYYYSS TSRPSAPPTS ATAFDHL
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Thought to encode a transcription factor. It may have a role in kidney cell differentiation. May play a regulatory role in mammalian development.

Gene References into Functions

Results show that in both 3- and 8-week-old offspring of the maternal group highly treated with E2, Pax8 was significantly up-regulated in thyroid glands, accompanied by the abnormal CpG island methylation status in the promoter region. PMID:27827435
PAX8 has a cell specific role in governing proliferation and migration in nontransformed ovarian surface epithelium cells compared to the oviductal cells, but its reduction in serous cancer cell lines provides a common mechanism for reducing cell survival. PMID:27129161
These results suggest that Pax8 maybe the downstream molecule of ALK3, it mediates the murine heart development via cellular senescence, which may serve as a mechanism that compensates for the cell loss via apoptosis in heart development. PMID:26781745
Mice lacking microRNAs in Pax8-expressing cells develop hypothyroidism and end-stage renal failure PMID:27090781
PAX8 protein expression was associated with germinal layers in human and murine forebrain and hindbrain development. PMID:25287489
Pax8 is essential for function and survival of adult thyroid cells. PMID:25127920
The Pax8 promoter appears to be autoregulated, a feature that might be responsible for the haploinsufficiency displayed by this gene. PMID:23078112
Inducible, Pax8-rtTA-based deletion of VHL leads to organ-specific expression of epithelial HIF and erythropoietin in liver and kidney without causing pathological changes. PMID:23384425
study concludes that Cadherin-16 is a novel downstream target of the transcription factor Pax8, likely since the early steps of thyroid development, and that its expression is associated with the fully differentiated state of the thyroid cell PMID:22135066
a thyroid-specific regulatory element in the 5' upstream region of the Pax8 gene PMID:20470391
The Box protein Pax-8 gene is an important and cardiac-specific ALK3 downstream gene in the BMP signaling pathway during inter-ventricular septum development. PMID:14731361
Pax8(-/-)TRalpha1(-/-) compound mutants die around weaning unless they are substituted with thyroid hormones. Short life span of Pax8(-/-) mice due to complex mechanism involving TRalpha2 and an unliganded TR isoform. PMID:15802493
Combination of partial deficiencies in the Titf1 and Pax8 genes results in an overt thyroid dysgenesis phenotype that is absent in either of the singly deficient, heterozygous mice. PMID:16150900
Pax8 expression not only in the uterine epithelium of mice but also in the human endometrium. Adequate development of uterus may be affected in congenital hypothyroid female patients with mutations in Pax8 gene. PMID:17082261
A 6h exposure to Tg resulted in increases of about 5-fold in TGF-beta1 and PAI-1 mRNA and a decrease of 53% in Pax-8. PMID:17495424