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Recombinant Mouse Oncostatin-M-specific receptor subunit beta (Osmr), partial

Recombinant Mouse Oncostatin-M-specific receptor subunit beta (Osmr), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Osmr

Uniprot NO.

O70458

Species

Mus musculus (Mouse)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events.

Gene References into Functions

OSMR-beta deficiency in macrophages improved high-fat diet-induced atherogenesis and plaque vulnerability PMID:28258089
Osmr expression in healthy mouse colon tissue was detected in endothelial and stromal cells. In agreement with observations of increased OSMR expression in inflamed colon tissue, the number of cells expressing Osmr was markedly increased in the lamina propria of mice with colitis. PMID:28368383
defects in OSM signaling promote the deterioration of high-fat diet-induced obesity and related metabolic disorders PMID:24695736
Data indicate that OSM receptor beta subunit-deficient (OSMRbeta(-/-)) mice exhibited phenotypic changes in adipose tissue macrophages (ATMs) to M1, increased proinflammatory cytokines in the adipose tissue, and systemic insulin resistance. PMID:23760275
These data indicate that the transient RANKL induction by intermittent PTH administration, which is associated with its anabolic action, is changed to a prolonged induction in OSMR-deficient osteoblasts, resulting in bone destruction. PMID:22190112
Bone formation can be stimulated independently of bone resorption and provide new insights into OSMR signaling. PMID:20051625
Expression of oncostatin M receptor beta in a specific subset of nociceptive sensory neurons. PMID:12814362
regulates hematopoiesis in vivo by stimulating stromal cells as well as hematopoietic progenitors, in particular megakaryocytic and erythrocytic progenitors. PMID:12855584
Mice deficient in OSM receptor showed impaired liver regeneration with persistent parenchymal necrosis after carbon tetrachloride exposure. Recovery of liver mass from partial hepatectomy was also significantly delayed in OSMR(-/-) mice. PMID:14999682
the up-regulation of p-STAT3 and p-CREB may be induced possibly through OSMR in inflammation PMID:15893881
These findings suggest that IL-31 and OSM may thus have redundant functions in the development of OSMRbeta-expressing neurons. PMID:16926070
Bone marrow progenitor cells involved in injured liver regeneration express OSMRB. PMID:17379762
IL-6 and Oncostatin M individually affect the profile of leukocyte trafficking PMID:18641356