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Recombinant Mouse Nuclear receptor subfamily 6 group A member 1 (Nr6a1)

Recombinant Mouse Nuclear receptor subfamily 6 group A member 1 (Nr6a1)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Nr6a1

Purity

>85% (SDS-PAGE)

Target Names

Nr6a1

Uniprot NO.

Q64249

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-495

Target Protein Sequence

MERDERPPSG GGGGGGSAGF LEPPAALPPP PRNGFCQDEL AELDPGTNGE TDSLTLGQGH IPVSVPDDRA EQRTCLICGD RATGLHYGII SCEGCKGFFK RSICNKRVYR CSRDKNCVMS RKQRNRCQYC RLLKCLQMGM NRKAIREDGM PGGRNKSIGP VQISEEEIER IMSGQEFEEE ANHWSNHGDS DHSSPGNRAS ESNQPSPGST LSSSRSVELN GFMAFRDQYM GMSVPPHYQY IPHLFSYSGH SPLLPPQARS LDPQSYSLIH QLMSAEDLEP LGTPMLIEDG YAVTQAELFA LLCRLADELL FRQIAWIKKL PFFCELSIKD YTCLLSSTWQ ELILLSSLTV YSKQIFGELA DVTAKYSPSD EELHRFSDEG MEVIERLIYL YHKFHQLKVS NEEYACMKAI NFLNQDIRGL TSASQLEQLN KRYWYICQDF TEYKYTHQPN RFPDLMMCLP EIRYIAGKMV NVPLEQLPLL FKVVLHSCKT STVKE
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Orphan nuclear receptor. Binds to a response element containing the sequence 5'-TCAAGGTCA-3'. May be involved in the regulation of gene expression in germ cell development during gametogenesis.

Gene References into Functions

Here, the authors present the first structure of mouse GCNF DNA-binding domain in complex with the Oct4 DR0. The overall structure revealed two molecules bound in a head-to-tail fashion on opposite sides of the DNA at a DR0 motif located within the Oct4 promoter. PMID:27984042
Inactivation of the Gcnf gene in vivo leads to loss of repression of Oct4 expression in both male and female gonads. PMID:25140725
Gcnf is expressed in fetal ovarian germ cells. PMID:23762465
characterize the let-7 target Nr6a1, an embryonic transcriptional repressor that regulates gene expression in adult fibroblasts following miRNA loss PMID:23630078
GCNF initiates the repression and epigenetic modification of Oct4 gene during ESC differentiation. PMID:21608077
These experiments confirmed that NR6A1 works as a regulator for hypocretin transcription. PMID:21056546
Examination of RTR expression in murine placental tissue by immunohistochemistry demonstrated the presence of RTR protein in the nuclei of giant trophoblasts and spongiotrophoblasts. PMID:11969338
embryonic function is dependent on the DNA binding site PMID:12381721
GCNF in early embryos is a maternal protein and could be involved in the regulation of zygotic gene expression and preimplantation embryonic development. PMID:12493724
germ cell nuclear factor plays a role in transcriptional regulation during meiosis and the early haploid phase of spermatogenesis PMID:12606326
androgen-regulated gene expressions located at the corpus principal cells might be controlled by GCNF. PMID:12639946
GCNF-dependent repression of Bmp15 and Gdf9 mediates gamete regulation of female fertility. PMID:12912906
germ cell nuclear factor (GCNF) may play an important role in epididymal differentiation PMID:15064830
Germ cell nuclear factor acts as a repressor of basal transcription on both the Protamine 1 and Protamine 2 promoters. PMID:15236322
Expression of GCNF may play important roles in spermatogenesis, capacitation and fertilization. PMID:15273870
The level of GCNF is critical for differentiation and maturation of neuronal precursor cells. PMID:15297607
Three hypersensitive sites were identified in the region spanning 2.1kb between the last exon of GCNF and the first exon of Ad4BP/SF-1. PMID:15737622
GCNF has a central role in the repression of pluripotency gene expression during retinoic acid-induced embryonic stem cell differentiation PMID:16166633
Required for establishment of the isthmic organizer, thereby regulating the midbrain development. PMID:16530751
We found that GCNF interacts directly with Dnmt3 molecule(s) and verified that this interaction induces the methylation of the Oct-3/4 promoter. PMID:16631596
These results suggested that GCNF might be a negative regulator of PPARdelta gene expression through its direct interaction with PPARdelta promoter in mouse testis. PMID:18330480
Nr6a1 is expressed not only in the germ cells of mouse but also in a variety of somatic tissues, including epididymis, oviduct, brain, and pituitary. PMID:19164181
The suppression of Oct4 by GCNF is important for the transition from primitive to definitive neural stem cells and restriction of the non-neural competency in the early neural stem cell lineage. PMID:19228964