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Recombinant Mouse Nuclear receptor corepressor 1 (Ncor1), partial

Recombinant Mouse Nuclear receptor corepressor 1 (Ncor1), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Ncor1

Purity

>85% (SDS-PAGE)

Target Names

Ncor1

Uniprot NO.

Q60974

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-2453

Target Protein Sequence

MSSSGYPPNQ GAFSTEQSRY PSHSVQYTFP SARHQQEFAV PDYRSSHLEV SQASQLLQQQ QQQQLRRRPS LLSEFHPGSD RPQERRSGYE QFHPGPSPVD HDSLESKRPR LEQVSDSHFQ RISAAVLPLV HTLPEGLRSS ANAKKDPAFG VKHEAPSSPL SGQPCGDDQN ASPSKLSKEE LIQSMDRVDR EIAKVEQQIL KLKKKQQQLE EEAAKPPEPE KPVSPPPVEQ KHRSIVQIIY DENRKKAEEA HKIFEGLGPK VELPLYNQPS DTKVYHENIK TNQVMRKKLI LFFKRRNHAR KQREQKICQR YDQLMEAWEK KVDRIENNPR RKAKESKTRE YYEKQFPEIR KQREQQERFQ RVGQRGAGLS ATIARSEHEI SEIIDGLSEQ ENNEKQMRQL SVIPPMMFDA EQRRVKFINM NGLMEDPMKV YKDRQFMNVW TDHEKEIFKD KFIQHPKNFG LIASYLERKS VPDCVLYYYL TKKNENYKAL VRRNYGKRRG RNQQIARPSQ EEKVEEKEED KAEKTEKKEE EKKDDEEKDD KEDSKETTKE KDRTEATAEE PEEREQVTPR GRKTANSQGR GKGRVTRSMT SEAAAANAAA AATEEPPPPL PPPPEPISTE PVETSRWTEE EMEVAKKGLV EHGRNWAAIA KMVGTKSEAQ CKNFYFNYKR RHNLDNLLQQ HKQKASRKPR EERDVSQCES VASTVSAQED EDIEASNEEE NPEDSEGAEN SSDTESAPSP SPVEAAKSSE DSSENAASRG NTEPVAELEA TTDPAPCASP SSAVPTTKPA ERESVEAQVT DSASAETAEP MDVDHEECGA EGSSVLDPPA PTKADSVDPE MQVPENTASK GEGDAKERDL ESTSEKTEAR DEDVVVAEQI ERPEPQSDDD SSATCSADEG VDGEPERQRV FPMDAKPSLL TPPGSILISS PIKPNLLDLP QLQHRAAVIP PMVSCTPCNI PIGTPVSGYA LYQRHIKAMH ESALLEEQRQ RQEQVDLECR SSTSPCSTSK SPNREWEVLQ PAPHQVITNL PEGVRLPTTR PTRPPPPLIP SSKTTVASEK PSFIMGGSIS QGTPGTYLSS HNQAYPQEAP KPSVGSISLG LPRQQESTKA APLTYIKQEE FSPRSQNSQP EGLLVRAQHE GVVRGTAGAV QEGSITRGTP ASKISVETIS SLRGSITQGT PALPQAGIPT EALVKGPVSR MPIEESSPEK VREEAASKGH VIYEGKSGHI LSYDNIKNAR EGTRSPRTAH EMSLKRSYEA VEGSIKQGMS MRESPVSAPL EGLICRALPR GSPHSDLKER TVLSGSIMQG TPRATAESFE DGLKYPKQIK RESPPIRAFE GAITKGKPYD GITTIKEMGR SIHEIPRQDI LTQESRKTPE VVQSTRPIIE GSISQGTPIK FDNNSGQSAI KHNVKSLITG PSKLPRGMLE IVPENIKVVE RGKYEDVKAG EPVRARHTSV VSSGPSVLRS TLHEAPKAQL SPGLYDDSSA RRTPVSYQNT ISRGSPMMNR TSDVSSSKSA SHERKSTLTP TQRESIPAKS PVPGVDPIVS HSPFDPHHRS SAAGEVYRSH LPTHLDPAMP FHRALDPAAA YLLQRQLSPT PGYPSQYQLY AMENTRQTIL NDYITSQQMQ VNLRPDVTRG LSPREQPLGL PYPATRGIID LTNMPPTILV PHAGGTSTPP MDRITYIPGT QVTFPPRPYN AASLSPGHPT HLAAAASAER EREREREKER ERERERERER ERERIAAAPA DLYLRPGSEQ PGRPGSHGYV RSPSPSVRTQ ETILQQRPSV FQGTNGTSVI TPLDPTAQLR IMPLPSGGPS ISQGLPASRY NTAADALAAL VDAAASAPQM DVSKTKESKH EAARLEENLR SRSAAVSEQQ QLEQKNLEVE KRSVQCVCTS SALPSGKAQP HASVVYSEAG KDKGPPPKSR YEEELRTRGK TTITAANFID VIITRQIASD KDARERGSQS SDSSSSLSSH RYETASDAIE VISPASSPAP PQEKPQAYQP DMVKANQAEN ESTRQYEGPL HHYRSQQESP SPQQQPPLPP SSQSEGMGQV PRTHRLITLA DHICQIITQD FARNQVPSQA STSTFQTSPS ALSSTPVRTK TSSRYSPESQ SQTVLHPRPG PRVSPENLVD KSRGSRPGKS PERSHIPSEP YEPISPPQGP AVHEKQDSML LLSQRGVDPA EQRSDSRSPG SISYLPSFFT KLESTSPMVK SKKQEIFRKL NSSGGGDSDM AAAQPGTEIF NLPAVTTSGA VSSRSHSFAD PASNLGLEDI IRKALMGSFD DKVEDHGVVM SHPVGIMPGS ASTSVVTSSE ARRDEGEPSP HAGVCKPKLI NKSNSRKSKS PIPGQSYLGT ERPSSVSSVH SEGDYHRQTP GWAWEDRPSS TGSTQFPYNP LTIRMLSSTP PTQIACAPSA ITQAAPHQQN RIWEREPAPL LSAQYETLSD SDD
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation. Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression. The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver.

Subcellular Location

Nucleus.

Protein Families

N-CoR nuclear receptor corepressors family

Tissue Specificity

Ubiquitous.

Database Links

UNIGENE: Mm.271814

STRING: 10090.ENSMUSP00000018645

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