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Recombinant Mouse Neurogenic locus notch homolog protein 4 (Notch4), partial

Recombinant Mouse Neurogenic locus notch homolog protein 4 (Notch4), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Notch4

Uniprot NO.

P31695

Species

Mus musculus (Mouse)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system.

Gene References into Functions

Report impaired Notch4 signaling in endothelial progenitor cells isolated from mouse Kawasaki disease model. PMID:28013300
Notch4-knock-out mice that also lacked Notch1, had defects in all vascular beds. PMID:27354212
Constitutively active Notch4 receptor elicits brain arteriovenous malformations through enlargement of capillary-like vessels. PMID:25468970
Notch4-deficient mice exhibited slightly delayed vessel growth in the retina, consistent with the novel finding that NOTCH4 protein is expressed in the newly formed vasculature. PMID:24667410
Notch4 normalization reduces blood vessel size in arteriovenous malformations PMID:22261032
results demonstrate that whey acidic protein promoter-Int3 has no oncogenic effect upon parity-identified mammary epithelial cells PMID:21666720
Results indicate the importance of Notch signaling in maintaining the lung vasculature and offer a new, reliable model with which to study the pathobiology of lung arteriovenous shunts and malformations. PMID:19933399
PBP is essential for the growth of Notch4-immortalized mammary cells by activating SOX10 expression, providing a potential molecular mechanism through which PBP regulates the growth of mammary stem/progenitor cells. PMID:19852756
Expression of activated Notch1 or Notch4 in endothelial cells causes transdifferentiation to a mesenchymal phenotype. Notch 4 is expressed in the ventricular outflow tract during stages of endocardial cushion formation. PMID:14988227
Mice carrying a R142C Notch4 knock-in mutation do not develop a CADSIL phenotype. PMID:15645445
Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice. PMID:15994223
Notch4 intracellular domain attenuates TGF-beta signaling in several cell types. PMID:16007227
DDL4/Notch4 and ephrin B2 pathways downstream of VEGF plays a key role in the abnormal remodeling of tumor vessels PMID:16951162
establish the molecular basis for a novel activator protein 1/glucocorticoid-Notch4 axis in vascular endothelium PMID:17220278
Endothelial Notch4 signaling induces hallmarks of brain arteriovenous malformations. PMID:18667694
Notch4-induced mammary tumor development is independent of the interaction between its intracellular domain and Rbpj. That interaction is needed for mammary gland development. PMID:18836481
These findings may suggest the existence of a structural difference(s) between laboratory and wild mice at the Notch-4 locus that regulates the integration of mouse mammary tumor virus proviral DNA. PMID:19329137

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Subcellular Location

Cell membrane; Single-pass type I membrane protein.; [Notch 4 intracellular domain]: Nucleus. Note=Following proteolytical processing NICD is translocated to the nucleus.

Protein Families

NOTCH family

Tissue Specificity

Highly expressed in lung, moderately in heart kidney, and at lower levels in the ovary and skeletal muscle. A very low expression is seen in the brain, intestine, liver and testis.

Database Links

UNIGENE: Mm.173813

KEGG: mmu:18132

STRING: 10090.ENSMUSP00000015612

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