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Recombinant Mouse Negative elongation factor D (Th1l)

Recombinant Mouse Negative elongation factor D (Th1l)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Th1l

Purity

>85% (SDS-PAGE)

Target Names

Nelfcd

Uniprot NO.

Q922L6

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-591

Target Protein Sequence

MAGPAPGTIM GEDYFGNASE WGEEADGGQH QEDDSGEGED DAEVQQECLH KFSTRDYIME PSIFNTLKRY FQAGGSPENV IQLLSENYTA VAQTVNLLAE WLIQTGVEPV QVQETVENHL KSLLIKHFDP RKADSIFTEE GETPAWLEQM IAHTTWRDLF YKLAEAHPDC LMLNFTVKLI SDAGYQGEIT SVSTACQQLE VFSRVLRTSL ATILDGGEEN LEKNLPEFAK MVCHGEHTYL FAQAMMSVLA QEEQGGSAVR RVAQEVQRFA QEKGHDASQI TLALGTAASY PRACQALGAM LSRGALNPAD ITVLFKMFTS MDPPPVELIR VPAFLDLFMQ SLFKPGAKIN QDHKHKYIHI LAYAASVVET WKKNKRVSIG KDELKSTSKA IETVHNLCCN ENKGASELVA ELSTLYQCIR FPVVAMGVLK WVDWTVSEPR YFQLQTDHTP VHLALLDEIS TCHQLLHPQV LQLLVKLFET EHSQLDVMEQ LELKKTLLDR MVHLLSRGYV LPVVSYIRKC LEKLDTDISL IRYFVTEVLD VIAPPYTSDF VQLFLPILEN DSIAGTIKAE GEHDPVTEFI AHCKSNFIVV N
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex.

Gene References into Functions

These results indicate that TH1 is a novel regulator to control the duration and magnitude of androgen signal transduction and might be directly involved in androgen-related developmental, physiological, and pathological processes. PMID:20069563
results indicated that Nrf2 protects against the development of pulmonary fibrosis by regulating the cellular redox level and lung Th1/Th2 balance. PMID:20298567
The gene expression of TH1 in mouse testis and changes of TH1 protein during postnatal development, were analyzed. PMID:16786193
In conclusion, our data suggest that RelB is an important target for morphine modulation of proinflammatory and Th1 cytokines. They also indicate that morphine uses multiple intracellular pathways to exert its generalized immunosuppression. PMID:17023558
TH1 interacts with PAK1 and specifically restricts the activation of MAPK modules through the upstream region of the MAPK pathway, thereby influencing cell migration. PMID:19136554