Recombinant Mouse NT-3 growth factor receptor (Ntrk3), partial

1. TrkC signals to the podocyte actin cytoskeleton to induce migration by phosphorylating WAVE2 Erk dependently. This signaling mechanism may be important for TrkC-mediated cytoskeletal dynamics in podocyte disease. PMID:29162704
2. In a retinitis pigmentosa mouse model, TrkC activity generates phosphorylated Erk, which upregulates glial TNF-alpha, causing selective neuronal death. PMID:29242588
3. our data suggest that Runx3 may play a crucial role in the development of DRGs by regulating the expression of Ntrk3 variants PMID:26061886
4. TrkC expression in E13.5 VCG neurons requires NeuroD and that TrkC expression may be necessary for the normal migration and innervations of those neurons. PMID:23652629
5. The dependence receptor TrkC interacts with Cobra1.TrkC killer fragment shuttles with Cobra1 to the mitochondria to engage apoptosis. PMID:24034695
6. ETV6-SAM domain interface mutations block ETV6-NTRK3-induced cellular transformation PMID:23798677
7. This study demonistrated that NTRK3 plays a role in panic disorder by regulating hippocampus-dependent fear memories. PMID:24048855
8. Despite elimination of TrkC mRNA, no differences in development of kindling were detected between TrkC conditional null and wild type control mice. PMID:22980123
9. Data suggest that postsynaptic TrkC trans interaction with presynaptic PTPsigma generates bidirectional adhesion and recruitment essential for excitatory synapse development and positions these signaling molecules at the center of synaptic pathways. PMID:21262467
10. Dok6 selectively binds to the NPQY motif of TrkC through its phosphotyrosine-binding (PTB) domain in a kinase activity-dependent manner. PMID:20565848
11. Transgenic mice overexpressing TrkC present susceptibility in their response to stress characterized by subtle changes in the HPA axis, marked changes in acute stress-induced brain activation and altered coping strategies. PMID:19698958
12. Data suggest that Runx3 is required for the specification of TrkC-expressing trigeminal ganglion neurons, conveying mechanoreceptive signals from the Merkel cells of the whisker vibrissae to the spinal trigeminal nucleus pars interpolaris. PMID:20034568
13. TrkC is expressed in the mouse cochlear nucleus by around post-natal day 8 and peaks around d30. TrkC immunostain was cytoplasmic. PMID:19610111
14. role of both full-length and truncated isoforms of trkC in Merkel innervation PMID:12117822
15. trkC detected in lung homogenate, on the surface of interstitial macrophages, but not in alveolar macrophages; a previously unknown trafficking signal occurs through neurotrophins in peripheral lung PMID:12122447
16. TrkC autophosphorylation is strongly induced by GM1 ganglioside PMID:12388556
17. TrkC deficient mice show proprioceptive afferent loss through selective neuronal cell death PMID:12732177
18. Increased expression of trkc in the mechanically compressed spinal cord of the spinal hyperostotic mouse (twy/twy). PMID:12774239
19. Esophageal intraganglionic laminar endings share neurotrophin dependence on TrkC with spinal proprioceptors and some cutaneous mechanosensors, in concurrence with their proposed function as vagal mechanosensors crucial for reflex peristalsis. PMID:14614961
20. Preferential expression of BETA2/NeuroD1 and TrkC in posterior lobes explains the earlier start of cell apoptosis and preferential loss of granule cells in the posterior lobes. PMID:16368089
21. TrkC, the NT3 receptor, is present in neural precursors prior to embryonic day E11 until after birth. PMID:16673387
22. Our results demonstrate that the elevated NT3-TrkC tone via overexpression of TrkC in the brain may constitute a molecular mechanism for the expression of anxiety and anxiety. PMID:16963267
23. Thus, our rAd-TrkC vector can transfect NSCs and produce functional TrkC receptors to promote neuronal differentiation of NSCs. PMID:17007838
24. These data indicate that TrkC induces the PI3K-Akt cascade through the activation of c-Src. PMID:17991742
25. higher expression of the orthologous murine Ntrk3 gene was also detected in the hypothalamus of the anx/anx mouse model of anorexia. PMID:18203754

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UNIGENE: Mm.119373

KEGG: mmu:18213

STRING: 10090.ENSMUSP00000037909