Recombinant Mouse NLR family member X1 (Nlrx1), partial

1. Data suggest that Nucleotide-binding domain and leucine-rich-repeat-containing family member X1 (NLRX1) acts as an important regulator of the cisplatin-elicited ototoxity. PMID:28287190
2. NLRX1 function extends to the control of hepatocyte energy metabolism via the restriction of mitochondrial fatty acid-dependent OXPHOS and enhancement of glycolysis. PMID:29514047
3. NLRX1 suppresses tumorigenesis and reveals new genetic pathways involved in the pathobiology of histiocytic sarcoma PMID:27105514
4. Nlrx1-/- mice exhibited significantly larger brain lesions and increased motor deficits following controlled cortical impact injury PMID:28993512
5. role in control of mitochondrial activity and prevention of oxidative stress and apoptosis in tissue injury PMID:28626071
6. this in vitro studies show that NLRX1-deficient T cells have a greater ability to differentiate into an inflammatory phenotype and possess greater proliferation rates PMID:28159898
7. NLRX1 diminishes Tumor Necrosis Factor-alpha-induced activation of both Akt- and NF-kappaB-dependent pathways. Since Akt was shown to be essential for Tumor Necrosis Factor-alpha-mediated activation of NF-kappaB it is likely that the primary effect of NLRX1 is at the level of C-Akt proein signaling. PMID:26971996
8. NLRX1 attenuated Apc(min/+) colon tumorigenesis, cellular proliferation, NF-KappaB, mitogen-activated protein kinase, signal transducer and activator of transcription 3 activation, and interleukin 6 levels. PMID:26971998
9. NLRX1 may relate to hair cell maturity, hearing formation and maintenance, and promote hair cell apoptosis through JNK pathway PMID:26836140
10. The regulatory role of NLRX1 in mechanisms of host tolerance employed by macrophages to respond to Helicobacter pylori infection.NLRX1 modulates innate immune responses to Helicobacter pylori infection. PMID:26367386
11. Nlrx1 may play an important role in neurodegenerative diseases, where necrosis is a prominent factor. PMID:25540124
12. These data support a model in which CS-dependent NLRX1 inhibition facilitates MAVS/RHL activation and subsequent inflammation, remodeling, protease, cell death, and inflammasome responses. PMID:25938787
13. The unique capacity of NLRX1 to regulate the cellular sensitivity toward intrinsic versus extrinsic apoptotic signals suggests a critical role for this protein in numerous physiological processes and pathological conditions. PMID:24867956
14. NLRX1 enhances macrophage antiviral immunity by interacting with influenza virus PB1-F2 protein, as well as preventing mitochondrial-induced apoptosis PMID:24799673
15. Analysis of the macrophage and microglial populations indicates that NLRX1 reduces activation during both active and passive EAE models PMID:24366868
16. does not participate in the negative regulation of MAVS-dependent antiviral responses PMID:23212541
17. NLRX1 attenuated IFN-I production & promoted autophagy during viral infection. NLRX1 interacts with TUFM. PMID:22749352
18. study identifies a previously unrecognized role for NLRX1 in the negative regulation of TLR-induced NF-kappaB activation by dynamically interacting with TRAF6 and the IKK complex PMID:21703539
19. NLRX1 interacts with TRAF6 and inhibits NF-kappaB activation PMID:21703540
20. the presence of NLRX1 is required for optimal chlamydial growth and reactive oxygen species production PMID:20959452

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UNIGENE: Mm.3957

KEGG: mmu:270151

STRING: 10090.ENSMUSP00000034621