Recombinant Mouse Mothers against decapentaplegic homolog 9 (Smad9)

1. Sphingosine 1 phosphate also up-regulated runt-related transcription factor 2 (Runx2) expression through S1PR2/RhoA/ROCK/Smad1/5/8 signaling. PMID:27612439
2. Phosphorylated Smad1/5/8/9 specifically bound to the BREs of Smad8/9 gene. The present study reveals that Smad8/9 is a unique R-Smad regulated through the BMP pathway at the mRNA level. PMID:26748560
3. findings suggest that Smad9 is a new type of transcriptional regulator in BMP signaling. PMID:25534700
4. The findings demonstrate for the first time that KMUP-1 can promote osteoblast maturation and differentiation in vitro via BMP-2/Smad1/5/8 and Wnt/beta-catenin pathways. PMID:25536014
5. Data indicate that PDGF-AA promotes mesenchymal stem cel migration via bone morphogenetic protein 2 (BMP2)-smad proteins smad1/5/8 activation requires lysosome-mediated degradation of PDGF alpha Receptor (PDGFRalpha). PMID:25470749
6. our data suggest a pivotal role for canonical BMP signaling demonstrating distinguished nonoverlapping function of pSmad8 with pSmad1 and pSmad5 in hfSCs regulation and hair morphogenesis but a redundant role in adult hair progenitors differentiation. PMID:24023003
7. FGF2 inhibited BMP9-induced osteogenic differentiation by blocking BMP9-induced Smads signaling and subsequently reducing Smads dependent up-regulation of ALK1 and ALK2 in mesenchymal stem cells. PMID:23680673
8. a detailed computational model for TGF-beta signalling that incorporates elements of previous models together with crosstalking between Smad1/5/8 and Smad2/3 channels through a negative feedback loop dependent on Smad7. PMID:23804438
9. BMP4-mediated signaling in adult mouse ovary-derived oogonial stem cells cultured in vitro drives differentiation of these cells into oocytes through Smad1/5/8 activation and transcriptional up-regulation of key meiosis-initiating genes. PMID:23993924
10. Endogenous FGF2 is necessary for BMP-2 induced nuclear accumulation and co-localization of Runx-2 and phospho-Smads1/5/8. PMID:23559326
11. Smad8/BMP2-engineered mesenchymal stem cells induce accelerated recovery of the biomechanical properties of the Achilles tendon PMID:22696396
12. Dynamic regulation of Smad expression during mesenchyme to epithelium transition in the metanephric kidney. PMID:11850197
13. Smad8 has critical function in the development of the mammalian central nervous system. PMID:15899870
14. results suggest that BMP2/BMP4 signalling through SMAD 8 is required for transcriptional activation of the mouse Msx1 gene PMID:16101586
15. we demonstrate that BMP-2, -5, and -7 stimulate receptor-activated Smad1, 5, and 8, which in turn causes oligomerization of Smad4 in the nucleus. PMID:16522160
16. Initially expressed only in the visceral yolk sac endoderm and shows a highly restricted pattern of expression in the embryo proper at later stages. PMID:16765933
17. Data show that Smad8 expression is ubiquitous during testis development but becomes cell-specific in the adult. PMID:18069690
18. Smad8 loss of function resulted in changes in pulmonary arteries including medial thickening and smooth muscle hyperplasia observed in patients with pulmonary artery hypertension. PMID:19419974

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UNIGENE: Mm.244353

KEGG: mmu:55994

STRING: 10090.ENSMUSP00000029371