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Recombinant Mouse Mitogen-activated protein kinase 13 (Mapk13)

Recombinant Mouse Mitogen-activated protein kinase 13 (Mapk13)

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MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Mapk13

Purity

>85% (SDS-PAGE)

Target Names

Mapk13

Uniprot NO.

Q9Z1B7

Alternative Names

Mapk13; Serk4; Mitogen-activated protein kinase 13; MAP kinase 13; MAPK 13; EC 2.7.11.24; Mitogen-activated protein kinase p38 delta; MAP kinase p38 delta; Stress-activated protein kinase 4

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-366

Target Protein Sequence

MSLTRKRGFY KQDINKTAWE LPKTYLAPAH VGSGAYGAVC SAIDKRTGEK VAIKKLSRPF QSEIFAKRAY RELLLLKHMH HENVIGLLDV FTPASSLRSF HDFYLVMPFM QTDLQKIMGM EFSEDKVQYL VYQMLKGLKY IHSAGIVHRD LKPGNLAVNE DCELKILDFG LARHTDTEMT GYVVTRWYRA PEVILSWMHY NQTVDIWSVG CIMAEMLTGK TLFKGKDYLD QLTQILKVTG VPGAEFVQKL KDKAAKSYIQ SLPQSPKKDF TQLFPRASPQ AADLLDKMLE LDVDKRLTAA QALAHPFFEP FRDPEEETEA QQPFDDALEH EKLSVDEWKQ HIYKEISNFS PIARKDSRRR SGMKLQ
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells.

Gene References into Functions

Study proposes MAPK p38delta protein as a key factor in breast cancer. PMID:28783172
Results reveal that p38delta contributes both cell-autonomous and paracrine effects during the course of skin tumor formation. PMID:25753147
p38gamma and p38delta reprogram liver metabolism by modulating neutrophil infiltration and provide a potential target for NAFLD therapy PMID:26843485
p38gamma and p38delta control heart growth by modulating mTOR pathway through DEPTOR phosphorylation and subsequent degradation. PMID:26795633
Together, our results establish that p38gamma and p38delta are central to colitis-associated colon cancer formation through regulation of hematopoietic cell response to injury, and validate p38gamma and p38kappa as potential targets for cancer therapy. PMID:25217523
p38gamma and p38delta are crucial regulators of inflammatory joint destruction in collagen-induced arthritis. PMID:24782184
GSK3alpha, GSK3beta, and MAPK13 were found to be the most active tau kinases, phosphorylating tau at all four epitopes. PMID:23798682
p27 inhibition of COX-2 expression was specifically due to phosphorylation of transcription factor cAMP response element binding (CREB) phosphorylation mediated by p38beta and p38delta. PMID:23639288
Aberrant p38delta-PKD1 signaling in neutrophils may underlie development of acute lung injury and life-threatening acute respiratory distress syndrome. PMID:23129748
results indicate that p38gamma and p38delta have a role in the suppression of tumor development PMID:21558321
Demonstrate roles of the p38alpha/beta/delta isoforms in the regulation of 12-O-tetradecanoylphorbol 13-acetate-induced skin inflammation. PMID:21336470
p38 has a role in mediating induction of VEGF mRNA expression by sodium arsenite PMID:12482858
sapk4 activation mediates apoptosis and neurodegeneration in infantile neuronal ceroid lipofuscinosis PMID:16644870
This study constitutes the first analysis addressing the functionality of p38beta, p38gamma and p38delta in satellite cell-dependent adult muscle regeneration and growth. PMID:18641461
Deletion of p38delta results in activation of protein kinase D (PKD), which has been identified as a regulator of stimulated insulin exocytosis; p38delta catalyzes an inhibitory phosphorylation of PKD1, thereby attenuating stimulated insulin secretion. PMID:19135240
An in vivo role for p38delta in promoting cell proliferation and tumor development in epidermis. PMID:19458068
Mouse embryonic stem cells lacking p38delta can differentiate to endothelial cells, smooth muscle cells, and epithelial cells. PMID:19539422