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Recombinant Mouse Mitochondrial import receptor subunit TOM70 (Tomm70a), partial

Recombinant Mouse Mitochondrial import receptor subunit TOM70 (Tomm70a), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Tomm70a

Purity

>85% (SDS-PAGE)

Target Names

Tomm70

Uniprot NO.

Q9CZW5

Species

Mus musculus (Mouse)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Acts as receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex). Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner. Mediates TBK1 and IRF3 activation induced by MAVS in response to virus infection and promotes host antiviral responses during virus infection.

Gene References into Functions

Genetic manipulation revealed that loss of Tom70 decreased mitochondrial MICU1 localization and aggravated myocardial ischemia/reperfusion injury; whereas, overexpression of Tom70 protected myocardial ischemia/reperfusion injury, which was eliminated by MICU1 ablation. PMID:28703803
Our findings showed that Tom70 is essential for melatonin-induced protection against post-myocardial infarction injury PMID:27706848
PINK1 is imported into mitochondria by a unique pathway that is independent of the TOM core complex but crucially depends on the import receptor Tom70 PMID:23472196
S100A2 and S100A6 interact with another TPR protein Tom70 and regulate the Tom70-ligand interaction in vitro PMID:18669640