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Recombinant Mouse Microtubule-actin cross-linking factor 1 (Macf1), partial

Recombinant Mouse Microtubule-actin cross-linking factor 1 (Macf1), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Macf1

Purity

>85% (SDS-PAGE)

Target Names

Macf1

Uniprot NO.

Q9QXZ0

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-7354

Target Protein Sequence

MSSSDEETLS ERSCRSERSC RSERSYRSER SGSLSPCPPG DTLPWNLPLH EQKKRKSQDS VLDPAERAVV RVADERDRVQ KKTFTKWVNK HLMKVRKHIN DLYEDLRDGH NLISLLEVLS GIKLPREKGR MRFHRLQNVQ IALDFLKQRQ VKLVNIRNDD ITDGNPKLTL GLIWTIILHF QISDIYISGE SGDMSAKEKL LLWTQKVTAG YTGVKCTNFS SCWSDGKMFN ALIHRYRPDL VDMERVQVQS NRENLEQAFE VAERLGVTRL LDAEDVDVPS PDEKSVITYV SSIYDAFPKV PEGGEGISAT EVDSRWQEYQ SRVDSLIPWI RQHTILMSDK SFPQNPVELK ALYNQYIHFK ETEILAKERE KGRIKELYKL LEVWIEFGRI KLPQGYHPNH VEEEWGKLIV EMLEREKSLR PAVERLELLL QIANKIQNGA LNCEEKLTLA KNTLQADAAH LESGQPVQCE SDVIMYIQEC EGLIRQLQVD LQILRDEKYY QLEELAFRVM RLQDELVTLR LECTNLYRKG HFSSLELVPP STLTTTHLKA EPLNKTTHSS STSWFRKPMT RTELVSISSS EDEGNLRFVY ELLSWVEEMQ MKLERAEWGN DLPSVELQLE TQQHIHTSVE ELGSSVKEAR LYEGKMSQNF HTSYVETLGK LETQYCKLKE TSSFRMRHLQ SLHKFVSRAT AELIWLNGKE EEELACDWSD SNPNISAKKT YFSELTMELE GKQDVFRSLQ DTAEVLSLEN HPAKQTVEAY SAAVQSQLQW MKQLCLCVEQ HVKENAAYFQ FFSDARDLES FLRNLQDSIK RKYTCDRSTS LSRLEDLLQD SMDEKEQLIQ SKSSVASLVG RSKTIVQLKP RNPDHVLKST LSVKAICDYR QIEITICKND ECVLEDNSQR TKWKVISPTG NEAMVPSVCF LIPPPNKEAI EMASRVEQSY QKVMALWHQL HINTKSLISW NYLRKDLDTV QTWSLEKLRS LAPGECHQVM KNLQAHYEDF LQDSHDSALF SVADRLRIEE EVEACKAHFQ HLMKSLENED KEETLAKVYI SELKNIRLLL EECEQRLLKQ IQSPASSKTD RDARQDITLR IAEQEHTQED LQHLRSDLDA ISMKCNVFLQ QSPSGSSATT LRSELNLMVE KMDHVYGLST VYLNKLKTID VIVRSMQDAE LLVKGYEIKL SQEEAVPADL SALESHRTTL QHWLSDVKDK NSVFSVLDEE ITKAKKVAEQ LRHPASEPNL DLERYQEKGS QLQERWHRVI AQLETRQSEV ESIQEVLRDY RACHGTLIKW IEETTAQQEM MKPGQAEDSR VLSEQLSQQT ELFAEIERNQ TKLDQCQKFS QQYSTIVKDY ELQLMTYKAF VESQQKSPGK RRRMISSSDA ITQEFMDLRT RYTALVTLTT QHVKYISDAL RRLEEEEKVV EEEKQEHVEK VKDLLGWVST LARNTQGTTT SSHTSASADI EKAILEQQVL AEELTTKKEQ VSEAIKTSQI FLAKHGHKLS EGEKEQISEQ LRVLNKTYHD LCDGSANQLQ QLQSELAQQT EQKGCRAVAG VIDLGTVEIF PIFRAMQKGL IDQDTGLVLL ESQIIMSGLI DPENSEKLSL EEGLTRNFIN LPIYQQLLGL RDSLSLVSRL TGTLGSLSVV EAIEKKIISE RLGLKVLEVH LATGGFSLPP SENCINLEEA FHQGFIASSL HSELQSHLRS SKNLIDPNTA EKVGLLDLMQ RCIIHQESGL KLLPVKQLAG GMVSLKSGRK VSIFRAVQEG LIDRQVTVRL LEAQLFAGGI VDPRTGHRLT VEEAVRHNLI DQDMACAILI RQLQTGGIID TVTGDRMTID EAVTNNLVAA KIALVILESL WSFMGLLLPE SGEILPITDA LEQGIVSTEL AHKILHNRQQ IEALFLPTLT EIWSWEKATE SGILDKDLVN NLRSVCIPDM MPHIQLADSA EQSKVGFAAG KPPVSGPREE GSSHGEKLLF QLMTHSYIHA HTGQRLLLLD QELVEMLTSR DDCQVILPEV FEIQHQRLNT SEALQELYTG TISQISSAKH PRKPCESQFL SQNKDYPSQE NCTEAKGERS VVGIECSPAE SPERELFLKE QEAIIENVGS LKVINKVKLK LQRPLLGSRK EEQAETLREE NISGDPLLVE CPEESEGKDL STEKSKCQTP TKCSFTCHKE QVKTIKDIPS ETGTSLIKSQ NQMSQFQVDT SVGLRSEFKS EHDMNVNSLE KELKEELLVK DGHKQSQEGQ SVADGQTVAL EKTDTEDNAD EPALLHSSPF EDATLSTLSA QLQDGGIFNE ETGQKLLLNE AIAQGLVSSH TAVKLMGKLN MFRGFFDSQT CESLTTEEVI DEGLMDEKLL YNVLMSDKAI SGILDPRTHS LCSVKEAVAA GLLDKETATR ILEGQVITGG IVDLKRGKKL SVTLASNLGL VDTADQTELI NLEKATKGRG AEKAVKERLI ELQMETAGLM DPESKAPLTV LQSIDRGILE REAAVYLLTK QVLDGGIIHH ISGLRLSVDN AFKHGLIGED MARQLRKVEN FIHYQFFHPQ TKEALSFSEA IKLDLVSPDL KREIQEIQDF SGNLGDFIYG QKLTLAKTNK EESLANKTEL PSGVMHGVID PENCTIIPYS ELVKKCRIDT ESGWRYLEVI PFSDIKDEAG NNVLTPPEAI QLGKVDFASA LKVLEAQANT GGIIDMATGK RVTLASALEK KLLDENMARI IASHQMLSGG IIDIYSDQRV TLNDAVEKRL ISPELAAMIQ VDPLAEQGGT GVCELKGDFL RKELLSESSK TPRESYSKEK HEAVLQAGSL CAPEKAGIRG SNGEKAEKGR KISVEMEGQR QDEKASSDSK VSASILSPFG FEGESSYQVS VTHPCSESCD LKPREETRSC MKKCAVVERD KVVTQIKMVS HVKQSTSGLD AEEARERQGR MVSKEQGSHY ETAGNLLSER SVRVDRRVRR EMGGEQSVQM SREAAVLSEE ESDQEVTIGD EPDSFVKSQS MKMIGNDKGK EAGIEKDISV VCKIEGFPSQ MTSKDASLTN QDALPFYTEG ETKTVNLCSI LKPGEKLSQE TASTVQKEPL SSEIPRPERL NSQESDEEPQ ISDVPHISKG DMAAQITTRQ ETTDVQDLYI TSKSSETKDK IFPSKNYIEK LHQEIPMDPT RSHKLKEATI STLETEGISY LDSSDIKSLC EDSKADHKSC GHQKSKVTTT QAKKSLEVVD LLVRDTEEGS SEDRVGQRGP RVLASLLPEK LPTRTVQSEN IRQHDAVIPA ISEIREEMAL SLPCSVVKVD GKIPKEKHKE ILGDEQGPFM AIPSGKGIEG VNPEPCRATQ NVFTRRLCLE HDEKLVSYLS LLRDIEMRTK QIQPLELNVA ELQDLLGQAK ELDRELKDLS TVVSQELECV DRIVISQPQE VPAQLLKALE KDAKNLQKSL DSVSDSWSSR FLHLQSAVEV KKATVLNRHK ELQGKLQDLR AWVGRASLTL NSKGCDTETD ADSLSHTLQP YKDMKQSMAE RKSQLDALAL DIQLFISEHP QDLSLQQNQE MLQFLSELQR SFQGLVEHTA AQKDVVQGHL QQVQQEVQVK TLQKQQDTCH KKLEDLCNWV GQAERALERH QGGSSSGKSS LLCAEPKVDL KDLQGDIQSH STSFATAVKD IEGFLEENQT KLSPQELTAL REKLHQAKEQ YEVLQERTRV AQKELEEAVT SALQQETEKS KAATELAENK RKIDALLDWV GLLWGHLRES HRLAFQEWSS SLELAMEKQT LAATDGHVDV NQVPETLDRQ YELMKARHQE LLSQQQNFIV ATQSVQSFLD QHSHNLTPEE RQKLQEKLGE LKEQYAASLA RSEAELKQTQ ALRDELQKFL QDHKEFENWL QQSENELDSM HKGGSSPEAL NSLLKRQGSF SEDVISHKGD LRFVTISGQK VLETENNFEE GQEPSATRNL VNEKLKDATE RYTTLHSKCI RLGSHLSMLL GQYQQFQSSA DSLQAWVLTC EASVGKLLSD TVASDPGVLQ QQLATTKQLQ EELAEHQVPV EKLQKAAHDL LDIEGEPALD CRPIQETTDS ISSRFQNLSC SLDERSALLQ KAIAQSQSVQ ESMESLLQSI REVEQNLERD QVASLSSGVI QEALANNMKL KQDIARQKSS LEATHDMVTR FMETADSNSA SVLQGKLAEL SQRFQQLQLQ QQEKESNLKK LLPQAEMFEQ LSNKLQQFME NKSRLLASGN QPDQDIAHFS QQIQELTLAM EDQKENLDTL EHLVTTLGSC GFALDLSQHQ DKIQNLKKDF TELQKTVQER EKDASTCQEQ LDEFRKLIRT FQKWLKETEG NVPPAKTFVS AKELEKQIEH LKDLISDWES KGALLGEINA KGTALESLIM DITAPDSQAK TGSILPPVGS SVGSVNGYHT CKDLTEIQCD MFDVNSKYEK LWEVLRERQE SLQTVFSRME EVQKEASSVL QWLESKEEVL KAMDATLSPT KTETVKAQAE SNKAFLAELE QNSPKIQKVK EALAGLLKTY PNSQEAENWK KMQEDLNSRW EKATEVTVAR QKQLEESASH LACFQAAESQ LRPWLMEKEL MMGVLGPLSI DPNMLKQQVQ FMLKEFEARR QQHEQLNEAA QGILTGPGDM SPSASQVHKD LQSISQKWVE LTDKLNSRSS QIDQAIVKST QYQDLLQDLS EKVKAIGQRL SGQSAISTQP EAVKQQLEET SEIRSDLGQL DNEIKEAQTL CQELSLLIGE QYLKDELKKR LETVALPLQG LEDLAADRMN RLQAALASTQ QFQQMFDELR TWLDEKQSQQ AKNCPISAKL ERLQCQLQEN EEFQKNLNQH SGSYEVIVAE GEALLLSVPP GEEKKTLQNQ LVELRSHWED LSKKTANRQS RLKDCMQKAQ KYQGHVEDLV PWIDECKSKM SELQVTLDPV QLESSLLRSK AMLNEAEKRR SLLEILNSAA DILINSSEID EDEIRDEKAG LNQNMDAITE ELQAKTSSLE EMTQRLKEFQ ESFKNIEKKV EGAKHQLEIF DALGSQACSN KNLEKLKAQQ EVLQALEPQV DYLRNFTQGL VEDAPDGSDA SPLVHQAEVA QQEFLEVKQR VSSSCLTMEN KLEGIGQFHC RVREMFSQLA DLDDELDGMG AIGRDTDSLQ SQIEDVRLFL NKIQALRFDI EDSEAECRKM LEEEGTLDLL GLKRELEALN KQCGKLTERG KVRQEQLELT LGRVEDFYRK LKALNDAATA AEEGEALQWI VGTEVDVINQ QLADFKLFQK DQVDPLQVKL QQVNGLGQGL IQSAGKNCDV QGLEHDMDEI NTRWNTLNKK VAQRIAQLQE ALLHCGKFQD ALEPLLSWLT DTEELIANQK PPSAEYKVVK AQIQEQKLLQ RLLDDRKATV DMLQAEGGRI AQSAELADRE KITGQLESLE RRWTDLLSKA AARQKQLEDI LVLAKQFHET AEPISDFLSV TANKLANSEP VGTQTAKIHQ QIIRHKALNE EIINRKKNVD QAIKNGQALL KQTTGEEVLL IQEKLDGIKT RYADITLTSS KALRTLEQAR QLATKFHSTY EELTGWLREA EEELAASGGQ SPTGEQIPQF QQRQKELKKE VMEHRLVLDT VNEVSHALLE LVPWRAREGL DKLVSDANEQ YKLISDTVGQ RVDEIDAAIQ RSQQYEQAAD AELAWVAETK RKLMALGPIR LEQDQTTAQL QVQKAFSIDI IRHKDSMDEL FSHRGEIFST CGEEQKAVLQ EKTECLIQQY EAVSLLNSER YARLERAQVL VNQFWETYEE LSPWAEETLA LIAQLPPPAV DHEQLRQQQE EMRQLRESIA EHKPHIDKIL KIGPQLKELN PEEGKMVEEK YQKAENMYAQ IKDEVRQRAL ALDEAVSQSA QFHDKIEPML ETLENLSSRL RMPPLIPAEV DKIRECISDN KSATVELEKL QPSFEALKRR GEELIGRSQG ADKDLAAKEI QDKLDQMVFF WEDIKARSEE REIKFLDVLE LAEKFWYDMA ALLTTIKDTQ DIVHDLESPG IDPSIIKQQV EAAETIKEET DGLHEELEFI RILGADLIFA CGETEKPEVK KSIDEMNNAW ENLNKTWKER LEKLEDAMQA AVQYQDTLQA MFDWLDNTVI KLCTMPPVGT DLNTVKDQLN EMKEFKVEVY QQQIEMEKLN HQGELMLKKA TDETDRDIIR EPLTELKHLW ENLGEKIAHR QHKLEGALLA LGQFQHALEE LMSWLTHTEE LLDAQRPISG DPKVIEVELA KHHVLKNDVL AHQATVATVN KAGSELLESS AGDDASSLRS RLETMNQCWE SVLQKTEERE QQLQSTLQQA QGFHSEIEDF LLELNRMENQ LSASKPTGGL PETAREQLDT HMELHSQLRA KEEIYNQLLD KGRLMLLSRG DSGSGSKTEQ SVALLEQKWH AVSSKVEERK SKLEEALSLA TEFQNSLQEF INWLTLAEQS LNIASPPSLI LNTVLSQIEE HKVFANEVND HRDQIIELDQ TGNQLKFLSQ KQDVVLIKNL LVSVQSRWEK VVQRSIERGR SLDDARKRAK QFHEAWKKLI DWLEDAESHL DSELEISNDP DKIKLQLSKH KEFQKTLGGK QPVYDTTIRT GRALKEKTLL AGDTQKLDNL LGEVRDKWDT VCGKSVERQH KLEEALLFSG QFMDALQALV DWLYKVEPQL AEDQPVHGDL DLVMNLMDAH KVFQKELGKR TGTVQVLKRS GRELIEGSRD DTTWVKGQLQ ELSTRWDTVC KLSVSKQSRL EQALKQAEEF RDTVHMLLEW LSEAEQTLRF RGALPDDTEA LQSLIDTHKE FMKKVEEKRV DVNTAVAMGE AILAVCHPDC ITTIKHWITI IRARFEEVLT WAKQHQQRLE TALSELVANA ELLEELLAWI QWAETTLIQR DQEPIPQNID RVKALITEHQ SFMEEMTRKQ PDVDRVTKTY KRKSVEPTHA PFMEKSRSGS RKSLNQPTPP PMPILSQSEA KNPRINQLSA RWQQVWLLAL ERQRKLNDAL DRLEELCPEL KEFANFDFDV WRKKYMRWMN HKKSRVMDFF RRIDKDQDGK ITRQEFIDGI LASKFPTTKL EMTAVADIFD RDGDGYIDYY EFVAALHPNK DAYRPTTDAD KIEDEVTRQV AQCKCAKRFQ VEQIGENKYR FFLGNQFGDS QQLRLVRILR STVMVRVGGG WMALDEFLVK NDPCRARGRT NIELREKFIL PEGASQGMTP FRSRGRRSKP SSRAASPTRS SSSASQSNHS CTSMPSSPAT PASGTKVISS SGSKLKRPTP AFHSSRTSLA GDTSNSSSPA STGAKANRAD PKKSASRPGS RAGSRAGSRA SSRRGSDASD FDLLETQSAC SDTSESSAAG GQGSSRRGLT KPSKIPTMSK KTTTASPRTP GPKR
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane. Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics. Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration. May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4. Plays a key role in wound healing and epidermal cell migration. Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells. As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development.

Subcellular Location

[Isoform 2]: Cytoplasm. Cytoplasm, cytoskeleton. Golgi apparatus. Cell membrane. Cell projection, ruffle membrane.; [Isoform 1]: Cytoplasm. Golgi apparatus.

Protein Families

Plakin or cytolinker family

Tissue Specificity

Enriched in the hair follicle stem cells (at protein level). Isoform 1 and isoform 2 are ubiquitous expressed, with higher levels seen in lung, heart, thymus, spleen and brain.

Database Links

UNIGENE: Mm.402299

STRING: 10090.ENSMUSP00000095507

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