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Recombinant Mouse Metabotropic glutamate receptor 8 (Grm8), partial

Recombinant Mouse Metabotropic glutamate receptor 8 (Grm8), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Grm8

Uniprot NO.

P47743

Species

Mus musculus (Mouse)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.

Gene References into Functions

the data of this study revealed very different roles for mGlu8 in amygdala synaptic transmission, fear learning and its expression PMID:23664812
In the dentate gyrus of mGluR8 receptor-deficient mice, effects from selective agonists are linked to the lateral and medial perforant pathway. PMID:23220400
mGluR8 is an important regulator of excitatory transmission in the bed nucleus of the stria terminalis, and is selectively disrupted by both acute and chronic stress. PMID:21451497
mGluR8 deficiency decreased measures of anxiety in the elevated plus maze and the acoustic startle response in female mice. PMID:20080129
Might be potential target for disorders with pathophysiological changes in brain areas where mGlu8 modulates glutamate and GABA transmission, especially in anxiety disorders involving exaggerated contextual fear. PMID:19740090
The role of mGluR8 as a presynaptic autoreceptor and its contribution to cognitive processes are hypothesized and the utility of gene targeting is discussed as compared to pharmacological methods. PMID:12213278
Naive mGlu8 receptor-deficient mice show increased anxiety-related behavior in the elevated plus maze in low illumination conditions (red light) compared to wild-type mice. PMID:12213279
The increased anxiety-related behavior of mGlu8 receptor knockout mice in the elevated plus maze is associated with an increased number of c-Fos positive cells in the centromedial nucleus of the thalamus compared with wild-type mice. PMID:12946709
Increased measures of anxiety and weight gain in mice lacking the group III metabotropic glutamate receptor mGluR8. PMID:16045496
mGluR8 was localized in two broad bands, one each in the OFF and ON layers of the IPL; mGluR8 immunoreactivity was evident in the OFF plexus of cholinergic amacrine cell processes PMID:17311335

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Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Families

G-protein coupled receptor 3 family

Tissue Specificity

Strongly expressed in olfactory bulb, accessory olfactory bulb, and mammillary body. Weaker expression in the retina, and in scattered cells in the cortex and hindbrain.

Database Links

UNIGENE: Mm.320732

KEGG: mmu:14823

STRING: 10090.ENSMUSP00000110978

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