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Recombinant Mouse Melanoma-derived growth regulatory protein (Mia)

Recombinant Mouse Melanoma-derived growth regulatory protein (Mia)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Mia

Purity

>85% (SDS-PAGE)

Target Names

Mia

Uniprot NO.

Q61865

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

23-130

Target Protein Sequence

DRAMPKLA DWKLCADEEC SHPISMAVAL QDYVAPDCRF LTIYRGQVVY VFSKLKGRGR LFWGGSVQGG YYGDLAARLG YFPSSIVRED LTLKPGKIDM KTDQWDFYCQ
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Elicits growth inhibition on melanoma cells in vitro as well as some other neuroectodermal tumors, including gliomas.

Gene References into Functions

The effects of MIA/CD-RAP on transcriptional regulation in chondrocytes, through the regulation of p54(nrb) via YBX1 contributes to the understanding of chondrogenesis. PMID:24349210
Attenuated LM expressing MIA. PMID:22886976
as observed in other knockout models of molecules important for cartilage development and differentiation, viability and functional integrity is reached by remarkable molecular redundancy in MIA/CD-RAP knockout mice. PMID:24269712
The cartilage protein melanoma inhibitory activity contributes to inflammatory arthritis. PMID:24287514
Expression analysis of cartilage tissue derived from MIA-/- mice revealed strong downregulation of nuclear RNA-binding protein 54-kDa. PMID:21368873
MIA/CD-RAP stabilizes cartilage differentiation and inhibits differentiation into bone potentially by regulating signaling processes during differentiation. PMID:20164682
transcriptional mechanism by which CD-RAP expression is suppressed by IL-1 beta PMID:12072435
Cdrap/Mia is located between two housekeeping genes PMID:15028289
DNA promoter segment from -2,251 bp to -2,068 bp of the CD-RAP gene contains elements critical for gene expression. It demonstrates activation or repression of gene expression in vitro and in vivo based on cell type and content of transcription factors. PMID:16250001
A potential tumor suppressor role of Mia/Cd-rap in pituitary cells. PMID:17914116
Microarray analysis showed significant reductions in the expression of several proteins in lung misexpressing MIA. PMID:18342301