Recombinant Mouse Mast/stem cell growth factor receptor Kit (Kit), partial

1. IGF-1 upregulated c-kit expression in c-kit-positive C-kit-positive cardiac stem cells (CSCs) resulting in enhanced CSC proliferation and migration by activating the PI3K/AKT/DNMT signaling pathway to epigenetically silence miR-193a, which negatively modifies the c-kit expression level. PMID:29467020
2. these observations imply that the expression of c-kit in the colonic epithelium is involved in the proliferation and permeability of the colonic epithelium. PMID:29935985
3. our study demonstrated that miR-143 mediates oxidative stress-induced autophagy to enhance the survival of c-kit(+) CPCs by targeting Atg7, which will provide a complementary approach for improving cardiac progenitor cells (CPCs)-based heart repair PMID:29858017
4. This study provides evidence that c-Kit signaling is required during arteriogenesis. Also, it strongly suggests a vascular role for c-Kit signaling because rescue of systemic c-Kit activity by bone marrow transplantation did not augment the functional recovery of Kit(W/W-v) mouse hindlimbs. PMID:29287914
5. The results of this study suggest that NAR relieves Lop-induced constipation by increasing the levels of interstitial cells of Cajal markers (c-Kit and SCF), as well as AQP3. Thus, NAR may be effective as a candidate in patients suffering from lifestyle-induced constipation. PMID:29207043
6. Among the cardiac c-kit(pos) cell cohort only a very small fraction has the phenotype and the differentiation/regenerative potential characteristics of true multipotent CSCs. PMID:28800128
7. data suggest that c-Kit negatively regulates bone turnover, and disrupted c-Kit signaling couples increased bone resorption with bone formation through osteoclast-derived Wnt 10 b PMID:27527615
8. Kit mutation is associated with gastrointestinal stromal tumor. PMID:28923937
9. Data collectively argue that mutations perturbing SCO1 function have tissue-specific consequences for the machinery that ultimately governs copper homeostasis, and further establish the importance of aberrant mitochondrial signaling to the etiology of copper handling disorders. PMID:28973536
10. After intestinal myenteric plexus ablation with benzalkonium chloride, adult neurogenesis was significantly induced in c-kit loss-of-function mutant mice (W/W(v)). Imatinib induced appearance of ectopic neurons after BAC treatment, even in wildtype mice. Adult neurogenesis in the enteric nervous system is negatively regulated by c-Kit signaling in vivo. PMID:27572504
11. This study indicated that c-Kit could be used as a potential therapeutic target for treatment of cardiac fibrosis. PMID:28780584
12. Activation of c-kit signalling by SCF promotes migration of cardiac stem cells with increased phosphorylation of CXCR4-serine 339, p38 mitogen-activated protein kinase (p38 MAPK) and extracellular regulated protein kinases 1/2 (ERK1/2). PMID:27245949
13. exposure of HSPCs to SCF and diminished number of c-Kit receptors in their cell membranes do not compromise the capacity of HSPCs to reconstitute damaged hematopoietic tissue. PMID:27040393
14. the stem cell gene Kit is regulated inversely from Krt5/Krt14 by RA signaling PMID:27884045
15. TPO and its receptor Mpl are dispensable for platelet survival in adult mice PMID:27344013
16. Artificially applied c-kit(+) cells interact with the target organ endothelium following ischemia reperfusion injury. This interaction seems to depend on TLR-MyD88 signaling. PMID:28363496
17. a critical role for PRL2 phosphatase in mediating Notch and c-Kit signals in early T cell progenitors, is reported. PMID:28009085
18. These results suggest that CD44(+)CD117(+) T cells are stem cells and a specific T-cell phenotype that initially develops in the thymus, but they do not progress through DN3 and DN4 stages, lack a DP stage, and potently suppress T-cell proliferation and modulate the CTLA-4 pathway. PMID:28279199
19. we studied the efficacy of ACK2, an antibody that blocks KIT, followed by low-dose irradiation as a preconditioning regimen for hematopoietic cell transplantation using a murine model of Mucopolysaccharidosis type II. PMID:27590924
20. Constitutive activation of c-Kit receptor in mice is associated with an increased cardiac myogenic and vasculogenic reparative potential after injury, with a significant improvement of survival. PMID:27468693
21. C-kit-positive hematopoietic stem/progenitor cells expressed significantly higher of Nox1 and catalase, but less of lactoperoxidase than in matured mononuclear cells. PMID:25451257
22. c-KIT signaling regulates self-renewal capacity and prevents neurodifferentiation in culture. PMID:27789621
23. These findings identify functional redundancy among Kit-dependent hematopoietic lineages and establish an unanticipated capacity of megakaryocytes to mediate IL-1-driven systemic inflammatory disease. PMID:28375155
24. WNT signaling at an early stage (E12-E15) of submandibular salivary gland (SMG) development inhibits end bud morphogenesis and differentiation into proacini by suppressing Kit expression. PMID:27161149
25. c-kit can reduce inflammation, positively modulate airway remodeling, and improve function in a mouse model of airway hyperresponsiveness PMID:28090152
26. Our KitD814V-triggered B-ALL mouse model might prove valuable for the identification of additional oncogenic mutations and mechanisms that may contribute to leukemogenesis in humans. PMID:27664314
27. Kit inactivation within oocytes also led to premature ovarian failure, albeit via a contrasting phenotype. Despite normal initial complements of primordial follicles, oocytes remained dormant with arrested oocyte maturation. Foxo3 protein localization in the nucleus versus cytoplasm explained both mutant phenotypes. PMID:27500836
28. sca-1 antibody reduces both CD34+/c-kit+ progenitor cell surge and vascular restenosis after endoluminal vascular injury in a murine model. PMID:27666446
29. These findings indicate the SCF/Kit signaling insufficiency may contribute to the underdevelopment of ICCs and intestinal motility dysfunction upon hypoxia exposure. PMID:28315973
30. we identified important roles for the GATA-2 C-ZnF in bone marrow hematopoiesis via control of c-Kit expression and HSC/HSPC survival. PMID:26660446
31. role of KIT in cutaneous mast cells in skin physiology and pathology PMID:26268458
32. IMC-G4 cells had an additional novel c-kit gene mutation of KIT-Tyr421Cys which is considered to induce neoplastic transformation of mouse mast cells PMID:26722383
33. This study presents a new interpretation for the contribution of Kit(+) cells to cardiomyocytes and shows that Kit genetic lineage tracing over-estimates the cardiogenic activity of Kit(+) cardiac stem cells. PMID:26634606
34. gene deficiency does not play a role in the pathogenesis of lupus in B6lpr/lpr mice. PMID:25849740
35. suggests FGF-9 has the potential to attenuate vascular cell apoptosis, activate c-Kit progenitor cells, and enhance angiogenesis and neovascularization in C57BL/6 and db/db mice leading to improved cardiac function. PMID:26682010
36. Bone marrow-derived CD117+ hematopoietic progenitor cells differentiate into thymic dendritic cells in the fetal thymus organ culture system in the presence of Flt3L. PMID:26397863
37. C-kit signaling has a role in proliferation and invasion of colorectal mucinous adenocarcinoma PMID:26356816
38. House dust mite allergens mediate the activation of ckit in dendritic cells via Tolllike receptor 2. PMID:26238189
39. Dynamic process of early thymic progenitor differentiation is paralleled by migration-dependent change to the supporting niche, and identify vascular endothelial cells as a thymic niche cell, with mKitL as a critical ligand. PMID:26780297
40. Findings indicate that CD45 antigen(+) and c-Kit protein(+) hematopoietic cells were more abundant in muscle than in bone marrow between embryonic 14.5 and 17.5 days. PMID:26389592
41. c-kit(+) cells in the murine heart are endothelial cells and not cardiac stem cells. PMID:26515110
42. As SALL4A is known to impair ZBTB16-mediated Kit repression [14], our study provides novel insights into the molecular mechanism by which ATRA could control KIT expression, and thereby the differentiation of Aal into A1 spermatogonia in vivo. PMID:26427057
43. Data show that PI3 kinase is an attractive therapeutic target in malignancies induced by proto-oncogene protein c-Kit mutations. PMID:26040420
44. Activation of KIT modulates the function of tumor necrosis factor-related apoptosis-inducing ligand receptor (TRAIL-R) in mast cells PMID:25833810
45. Embryonic stem cells - derived c-Kit+/Sca-1-cells can be differentiated through a Klf4/beta-catenin dependent pathway and are a suitable source of vascular progenitors for the creation of superior tissue-engineered vessels from decellularised scaffolds. PMID:25985152
46. SCF/c-kit signaling was required for TPA-induced migration and differentiation of hair follicle melanocytes. PMID:25727244
47. These results show that a crosstalk between Kit and erythropoietin receptor signaling cascades exists and that continuous Kit signaling, partly mediated by the MAPK pathway, interferes with this crosstalk. PMID:25323585
48. gene deficiency results in resistance to induction of intravenous tolerance in experimental autoimmune encephalomyelitis PMID:25588867
49. Data indicate that proto-oncogene protein Kit(w-sh) mice showed an unaltered capacity to develop lung pathology and increased mucus production in response to house dust mite (HDM). PMID:24157568
50. expression in adipose tissues responsive to food availability and environmental temperature; expression altered in obese mice PMID:24999927

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UNIGENE: Mm.247073

KEGG: mmu:16590

STRING: 10090.ENSMUSP00000005815