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Recombinant Mouse Mastermind-like protein 1 (Maml1), partial

Recombinant Mouse Mastermind-like protein 1 (Maml1), partial

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MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Maml1

Purity

>85% (SDS-PAGE)

Target Names

Maml1

Uniprot NO.

Q6T264

Alternative Names

Maml1; Kiaa0200Mastermind-like protein 1; Mam-1

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-1020

Target Protein Sequence

MVLPTCPMAE FALPRHSAVM ERLRRRIELC RRHHSTCEAR YEAVSPERLE LERQHTFALH QRCIQAKAKR AGKHRQPPAA ATAPVAAPAP ASAPAAARLD AADGPEHGRP VAHLHDTVKR SLDSAASPQN GDQPNGYGDL FPGHKKTRRE APLGVSVSAN GLPPASPLGQ PDKPSGGDTL QTAGKHSLGL DPINKKCLAD SGIHLNGGSN SSEPFPLSLS KELKQEPVDD LPCMIAGAGG SVAQSNLMPD LNLNEQEWKE LIEELNRSVP DEDMKDLFTE DFEEKKDPEP PGSATQTPLA QDINIKTEFS PAAFEQEQLG SPQVRAGSAG QTFLGASSAP VGTDSPSLGS SQTLFHTTSQ PGVDNSSPNL MPASAQAQSA QRALTSVVLP SQGPGGASEL SSAHQLQQIA AKQKREQMLQ NPQQAAPAPG PGQLATWQQA GPSHSPLDVP YPMEKPASPS GYKQDFTNSK LLMMPGVNKS SPRPGGPYLQ PSHSNLLSHQ SPSNLNQNPV NNQGSVLDYG NTKPLSHYKA DCGQGGPGSG QNKPALMAYL PQQLPHLSNE QNSLFLMKPK SGNMPFRSLV PPGQEQNPSS VPVAAPAASV GTQPTVSVAS THNSSPYLSS QQQAAVMKQH QLLLDQQKQR EQQQQQLQQQ QFLQRQHLLA EQEKQQFQRH LTRPPPQYQD PTQSTFPQQV GQFTGPSAAV PGMNNLGPSN SSCPRVFPQP GTLMSMGPGH APVSSLPSSS GQQDRGVAQF TGSQSLPQNS LYGMASGLAQ IVAQPPPQAT STHAHIPRQT NVGQNASTSA AYGQNSLGSA SLSQQHSKGT LPPGLTKPQV PRVSAAMGSQ NASWQHQGMP NLSSQTSGNS SVNPFTAAPS FHIQQAHLKL AGQQFSQAMP SRPMAPLSSA GAAGPMLPPV SAQQRNSAPA SAPPQAAPQQ GLPGLSPSGP ELGAFGQSPT SQMSGRPGLH CAQAYPVRTM GQELPFAYSG QPGSSGLSSV AGHTDLIDSL LKNRTSEEWI NELDDLLGSQ
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.

Gene References into Functions

The present study shows a new role for Maml1 as a component of Shh signaling, which plays a crucial role in both development and tumorigenesis. PMID:28726779
Similar phenotypes were observed by conditionally misexpressing a dominant negative form of MAML1 in Mitral cells ( MCs)after their migration. Furthermore, the intracellular domain of Notch1 (NICD1) was localized to nuclei of MCs. These findings suggest that Notch signaling at embryonic stages is involved in the dendritic complexity of MCs PMID:28027303
These observations suggest that chondrocyte maturation was impaired in MAML1(-/-) mice. MAML1 enhances the transcriptional activity of Runx2 and plays a role in bone development. PMID:23326237
This study demonstrated that targeting Maml1-induced tumor cell senescence and differentiation may alter the tumor microenvironment and cytokine and chemokine profiles and may also promote innate and adaptive immune cell infiltration and function. PMID:22864395
Maml-mediated Notch signaling plays a pivotal role in the initiation and maintenance of goblet cell differentiation for normal ocular surface morphogenesis. PMID:23293291
Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are essential for Notch signaling in vivo. PMID:22069191
Data demonstrate that Mesp2 potently represses Notch signaling by inducing the destabilization of mastermind-like 1, a core regulator of this pathway. PMID:21098559
MAML1 is a novel modulator for NF-kappaB signaling and regulates cellular survival. PMID:20231278
There seems to be close correlation of the spatial and temporal expression of Maml1, in the central nervous system (CNS) during early development, implicating a role for the Maml1 gene in neurogenesis. PMID:15019995
a dominant negative mutant of MAML1 resulted in early inhibition of T-cell development and the appearance of intrathymic B cells, phenotypes consistent with Notch1 inhibition PMID:15187027
MAML1 acts as a coactivator for MEF2C transcription and is essential for proper muscle development PMID:16510869
Mam-1 is required to some extent for Notch-dependent stages in lymphopoiesis, thus supporting the notion that Mam is an essential component of the canonical Notch pathway in mammals. PMID:17535917
Maml1 is specifically required for Notch2 signaling in marginal zone B cells. PMID:17699740

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Subcellular Location

Nucleus speckle. Note=Nuclear, in a punctate manner.

Protein Families

Mastermind family

Tissue Specificity

At E9.5, strongly expressed in the telencephalon, first branchial arch, forelimb buds and somites. By E10.5, continuously expressed in brain and spinal cord. Also expressed in first and second branchial arches and limb buds. By E11.5, expression in CNS is

Database Links

UNIGENE: Mm.51116

KEGG: mmu:103806

STRING: 10090.ENSMUSP00000059210

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