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Recombinant Mouse Mannose-binding protein C (Mbl2)

Recombinant Mouse Mannose-binding protein C (Mbl2)

Baculovirus
Mammalian cell

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Mbl2

Uniprot NO.

P41317

Alternative Names

Mbl2Mannose-binding protein C; MBP-C; Mannan-binding protein; RA-reactive factor P28A subunit; RARF/P28A

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

19-244

Target Protein Sequence

ET LTEGVQNSCP VVTCSSPGLN GFPGKDGRDG AKGEKGEPGQ GLRGLQGPPG KVGPTGPPGN PGLKGAVGPK GDRGDRAEFD TSEIDSEIAA LRSELRALRN WVLFSLSEKV GKKYFVSSVK KMSLDRVKAL CSEFQGSVAT PRNAEENSAI QKVAKDIAYL GITDVRVEGS FEDLTGNRVR YTNWNDGEPN NTGDGEDCVV ILGNGKWNDV PCSDSFLAIC EFSD
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages.

Gene References into Functions

this study shows that MBL-C expression is induced in the gut in response to Candida albicans sensing and is required for intestinal homeostasis and host defense against Candida albicans PMID:26442658
Human and murine data together indicate that SP-A, SP-D and MBL are synthesized in early gestational tissues, and may contribute to regulation of immune response at the feto-maternal interface during pregnancy. PMID:26603976
These data show that modulation of MBL is involved in the protection against renal I/RI induced by dietary restriction, and suggest that the mechanisms of protection induced by dietary restriction and fasting may be different. PMID:26367533
demonstrate that apolipoprotein E (Apoe), mannose-binding lectin 2 (Mbl2), and parotid secretory protein (Psp) are present at significantly different quantities in depleted plasma of diabetic NZO mice compared to non-diabetic controls PMID:23350727
These observations point to a previously unappreciated role for MBL in regulating host resistance and cardiac inflammation during infection with a major human pathogen. PMID:23139754
MBL plays a key role in clearing influenza A virus and maintaining lung homeostasis. PMID:21182784
present in the decidua in abortion-prone mating combinations PMID:19854517
selectively expressed in villous epithelial cells of the small intestine PMID:12471128
role for MBL in clearance of dying cells PMID:15749852
exposure of MBL to Kupffer cells increased cell surface SR-A expression and phagocytosis of S. aureus and E. coli; and MBL bound to lipid A, LPS, and S. aureus PMID:17015738
MBL as an important molecule in the maintenance of the homeostatic balance in the skin PMID:17363917
both the presence of capsule and wild-type cell wall architecture preclude MBL binding to C. neoformans. PMID:17646356
The in vitro binding and activation of the human and mouse complement systems was analysed and the susceptibility to infection in complement-deficient mouse strains, was tested. PMID:18501966
These model studies have uncovered unexpected roles of MBL and evidence of its interaction with other molecules of the innate immune system. PMID:19021581
mMBL-C may protect host intestinal mucosa by directly binding to the bacteria. PMID:19684159